List of highways bypassed by Interstate Highways

This is a list of highways, mostly U.S. Routes, bypassed by Interstate Highways. Unless otherwise specified, designations are as of ca. 1960, at the time the final Interstate plan was adopted. Interstates marked as "later addition" were added after the early 1960s. Locations and corridors are approximate.

;Interstate 4
*U.S. Route 92, St. Petersburg, Florida to Daytona Beach, Florida

;Interstate 5 (including Interstate 5E)
*U.S. Route 101, Los Angeles, California to San Ysidro, California
*U.S. Route 99, Los Angeles to Sacramento, California
*U.S. Route 99W, Sacramento to Red Bluff, California
*U.S. Route 99, Red Bluff to Junction City, Oregon
*U.S. Route 99E, Junction City to Portland, Oregon
*U.S. Route 99, Portland to Blaine, Washington

;Interstate 5W (now Interstate 580, Interstate 80 and Interstate 505)
*U.S. Route 50, Stockton, California to Oakland, California
*U.S. Route 40, Oakland to west of Sacramento, California
*U.S. Route 99W, west of Sacramento to northwest of Sacramento

;Interstate 8
*U.S. Route 80, San Diego, California to Gila Bend, Arizona
*State Route 84, Gila Bend to Casa Grande, Arizona

;Interstate 10
*U.S. Route 66, Santa Monica, California to Los Angeles, California
*U.S. Route 70 (also U.S. Route 99 and U.S. Route 60), Los Angeles to Phoenix, Arizona
*U.S. Route 80, Phoenix to Benson, Arizona
*State Route 86 and State Road 14, Benson to Lordsburg, New Mexico
*U.S. Route 80, Lordsburg to east of Van Horn, Texas
*U.S. Route 290, east of Van Horn to east of Junction, Texas
*State Highway 27, east of Junction to Comfort, Texas
*U.S. Route 87, Comfort to San Antonio, Texas
*U.S. Route 90, San Antonio to Lafayette, Louisiana
*New route, Lafayette to Baton Rouge, Louisiana
*U.S. Route 61, Baton Rouge to New Orleans, Louisiana
*U.S. Route 90, New Orleans to Jacksonville, Florida

;Interstate 12
*U.S. Route 190, Baton Rouge, Louisiana to Slidell, Louisiana

;Interstate 15
*U.S. Route 395, San Diego, California to San Bernardino, California (added 1968)
*U.S. Route 91, San Bernardino to Brigham City, Utah
*U.S. Route 191, Brigham City to Downey, Idaho
*U.S. Route 91, Downey to Sweetgrass, Montana

;Interstate 15W (Idaho) (now Interstate 86)
*U.S. Route 30N, Burley, Idaho to Pocatello, Idaho

;Interstate 16
*U.S. Route 80, Macon, Georgia to Savannah, Georgia

;Interstate 17
*State Route 69 and State Route 79 (roughly U.S. Route 89), Phoenix, Arizona to Flagstaff, Arizona

;Interstate 19
*U.S. Route 89, Nogales, Arizona to Tucson, Arizona

;Interstate 20
*U.S. Route 80, east of Van Horn, Texas to Meridian, Mississippi
*U.S. Route 11, Meridian to Birmingham, Alabama
*U.S. Route 78, Birmingham to Augusta, Georgia
*U.S. Route 1, Augusta to Columbia, South Carolina
*U.S. Route 76, Columbia to Florence, South Carolina

;Interstate 22
*U.S. Route 78, Memphis, Tennessee to Birmingham, Alabama (later addition)

;Interstate 24
*New route, south of Marion, Illinois to Vienna, Illinois
*U.S. Route 45, Vienna to Paducah, Kentucky
*U.S. Route 62, Paducah to Princeton, Kentucky
*U.S. Route 41, Princeton to Chattanooga, Tennessee

;Interstate 25
*U.S. Route 85, Las Cruces, New Mexico to Denver, Colorado
*U.S. Route 87, Denver to Buffalo, Wyoming

;Interstate 26
*U.S. Route 23, Kingsport, Tennessee to Asheville, North Carolina (later addition)
*U.S. Route 25, Asheville to Hendersonville, North Carolina
*U.S. Route 176, Hendersonville to Spartanburg, South Carolina
*New route, Spartanburg to Clinton, South Carolina
*U.S. Route 76, Clinton to Columbia, South Carolina
*U.S. Route 176, Columbia to Charleston, South Carolina

;Interstate 27
*U.S. Route 87, Lubbock, Texas to Amarillo, Texas (later addition)

;Interstate 29
*U.S. Route 71, Kansas City, Missouri to St. Joseph, Missouri
*U.S. Route 275, St. Joseph to Council Bluffs, Iowa
*U.S. Route 75, Council Bluffs to Sioux City, Iowa
*U.S. Route 77, Sioux City to Watertown, South Dakota
*U.S. Route 81, Watertown to Pembina, North Dakota

;Interstate 30
*U.S. Route 67, Dallas, Texas to Little Rock, Arkansas

;Interstate 35 (including Interstate 35E (Texas))
*U.S. Route 81, Laredo, Texas to Hillsboro, Texas
*U.S. Route 77, Hillsboro to Wichita, Kansas
*U.S. Route 50, Wichita to Kansas City, Missouri
*U.S. Route 69, Kansas City to Albert Lea, Minnesota
*U.S. Route 65, Albert Lea to Minneapolis-St. Paul, Minnesota
*U.S. Route 61, Minneapolis-St. Paul to Duluth, Minnesota

;Interstate 35W (Texas)
*U.S. Route 81, Hillsboro, Texas to Fort Worth, Texas
*U.S. Route 377, Fort Worth to Denton, Texas

;Interstate 35W (Kansas) (now Interstate 135)
*U.S. Route 81, Wichita, Kansas to Salina, Kansas

;Interstate 37
*State Highway 9 (roughly U.S. Route 181), Corpus Christi, Texas to north of George West, Texas
*U.S. Route 281, north of George West to San Antonio, Texas

;Interstate 39
*U.S. Route 51, Bloomington-Normal, Illinois to Wausau, Wisconsin (later addition)

;Interstate 40
*U.S. Route 66, Barstow, California to Oklahoma City, Oklahoma
*U.S. Route 62, Oklahoma City to Henryetta, Oklahoma
*U.S. Route 266, Henryetta to Warner, Oklahoma
*U.S. Route 64, Warner to Conway, Arkansas
*U.S. Route 65, Conway to Little Rock, Arkansas
*U.S. Route 70, Little Rock to Statesville, North Carolina
*U.S. Route 64, Statesville to Mocksville, North Carolina
*U.S. Route 158, Mocksville to Winston-Salem, North Carolina
*U.S. Route 421, Winston-Salem to Greensboro, North Carolina
*U.S. Route 70, Greensboro to Selma, North Carolina (later addition)
*U.S. Route 701 and U.S. Route 117, Selma to Wilmington, North Carolina (later addition)

;Interstate 43
*Highway 15, Beloit, Wisconsin to Milwaukee, Wisconsin (later addition)
*U.S. Route 141, Milwaukee to Green Bay, Wisconsin (later addition)

;Interstate 44
*U.S. Route 277, Wichita Falls, Texas to Oklahoma City, Oklahoma (later addition)
*U.S. Route 66, Oklahoma City to St. Louis, Missouri

;Interstate 45
*U.S. Route 75, Galveston, Texas to Dallas, Texas

;Interstate 49
*U.S. Route 167, Lafayette, Louisiana to Alexandria, Louisiana (later addition)
*Louisiana Highway 1 (roughly U.S. Route 71), Alexandria to Shreveport, Louisiana

;Interstate 55
*U.S. Route 51, New Orleans, Louisiana to Memphis, Tennessee
*U.S. Route 61, Memphis to St. Louis, Missouri
*U.S. Route 66, St. Louis to Chicago, Illinois

;Interstate 57
*U.S. Route 60, Sikeston, Missouri to Cairo, Illinois
*Illinois Route 37 (roughly U.S. Route 51), Cairo to Effingham, Illinois
*U.S. Route 45, Effingham to Chicago, Illinois

;Interstate 59
*U.S. Route 11, Slidell, Louisiana to Chattanooga, Tennessee

;Interstate 64
*U.S. Route 460, St. Louis, Missouri to Louisville, Kentucky
*U.S. Route 60, Louisville to Lexington, Virginia
*U.S. Route 11, Lexington to Staunton, Virginia
*U.S. Route 250, Staunton to Richmond, Virginia
*U.S. Route 60, Richmond to Norfolk, Virginia

;Interstate 65
*U.S. Route 31, Mobile, Alabama to Nashville, Tennessee
*U.S. Route 31W, Nashville to Louisville, Kentucky
*U.S. Route 31, Louisville to Indianapolis, Indiana
*U.S. Route 52, Indianapolis to Kentland, Indiana
*U.S. Route 41, Kentland to Chicago, Illinois

;Interstate 66
*Route 55, Strasburg, Virginia to east of Warrenton, Virginia
*U.S. Route 29, east of Warrenton to Washington, DC

;Interstate 68
*West Virginia Route 73, West Virginia Route 26, Pennsylvania Route 281 and U.S. Route 40, Morgantown, West Virginia to Hancock, Maryland (later addition)

;Interstate 69
*State Road 37, Indianapolis, Indiana to Fort Wayne, Indiana
*U.S. Route 27, Fort Wayne to east of Battle Creek, Michigan
*U.S. Route 27, east of Battle Creek to Lansing, Michigan (later addition)
*M-78, Lansing to Flint, Michigan (later addition)
*M-21, Flint to Port Huron, Michigan (later addition)

;Interstate 70 (including Interstate 70N)
*New route (partly U.S. Route 89), Cove Fort, Utah to Green River, Utah
*U.S. Route 6, Green River to Denver, Colorado
*U.S. Route 40, Denver to Limon, Colorado
*U.S. Route 24, Limon to Oakley, Kansas
*U.S. Route 40, Oakley to Washington, Pennsylvania
*U.S. Route 19, Washington to Pittsburgh, Pennsylvania
*U.S. Route 30, Pittsburgh to Breezewood, Pennsylvania
*Pennsylvania Route 126 and U.S. Route 522, Breezewood to Hancock, Maryland
*U.S. Route 40, Hancock to Baltimore, Maryland

;Interstate 70S (Pennsylvania)
*Pennsylvania Route 71, Washington, Pennsylvania to Greensburg, Pennsylvania

;Interstate 70S (Maryland) (now Interstate 270)
*U.S. Route 240, Frederick, Maryland to Washington, DC

;Interstate 71
*U.S. Route 42, Louisville, Kentucky to Cleveland, Ohio (passing through Columbus, Ohio via U.S. Route 22, U.S. Route 62, State Route 3 and State Route 61)

;Interstate 72
*U.S. Route 36, Hannibal, Missouri to Champaign-Urbana, Illinois (later addition)

;Interstate 73
*U.S. Route 220, Rockingham, North Carolina to Greensboro, North Carolina (later addition)

;Interstate 74
*U.S. Route 150, Moline, Illinois to Danville, Illinois
*U.S. Route 136, Danville to Indianapolis, Indiana
*U.S. Route 52, Indianapolis to Cincinnati, Ohio
*U.S. Route 52, Mount Airy, North Carolina to Winston-Salem, North Carolina (later addition)
*U.S. Route 311, Winston-Salem to Asheboro, North Carolina (later addition)
*U.S. Route 220, Asheboro to Rockingham, North Carolina (later addition)

;Interstate 75
*U.S. Route 41, Naples, Florida to Chattanooga, Tennessee
*U.S. Route 11, Chattanooga to Knoxville, Tennessee
*U.S. Route 25W, Knoxville to Corbin, Kentucky
*U.S. Route 25, Corbin to Detroit, Michigan
*U.S. Route 10, Detroit to Bay City, Michigan
*M-76, Bay City to Grayling, Michigan
*U.S. Route 27, Grayling to St. Ignace, Michigan
*U.S. Route 2, St. Ignace to Sault Ste. Marie, Michigan

;Interstate 77
*U.S. Route 21, Columbia, South Carolina to Charlotte, North Carolina (later addition)
*U.S. Route 21, Charlotte to Cleveland, Ohio

;Interstate 78
*U.S. Route 22, Harrisburg, Pennsylvania to New York, New York

;Interstate 79
*U.S. Route 119, Charleston, West Virginia to Weston, West Virginia (added in 1963)
*U.S. Route 19, Weston to Pittsburgh, Pennsylvania (added in 1963)
*U.S. Route 19, Pittsburgh to Erie, Pennsylvania

;Interstate 80
*U.S. Route 40, San Francisco, California to east of Salt Lake City, Utah
*U.S. Route 189, East of Salt Lake City to Echo, Utah
*U.S. Route 30S, Echo to Granger, Wyoming
*U.S. Route 30, Granger to Grand Island, Nebraska
*U.S. Route 34, Grand Island to Lincoln, Nebraska
*U.S. Route 6, Lincoln to Chicago, Illinois
*U.S. Route 20, Chicago to Norwalk, Ohio
*State Route 18, Norwalk to Youngstown, Ohio
*New route (partly U.S. Route 62 and U.S. Route 322), Youngstown to Stroudsburg, Pennsylvania
*U.S. Route 46, Stroudsburg to New York, New York

;Interstate 80N (west) (now Interstate 84)
*U.S. Route 30, Portland, Oregon to Burley, Idaho
*U.S. Route 30S, Burley to Echo, Utah

;Interstate 80S (Colorado) (now Interstate 76)
*U.S. Route 6, Denver, Colorado to Sterling, Colorado
*U.S. Route 138, Sterling to Big Springs, Nebraska

;Interstate 80S (Pennsylvania) (now Interstate 76)
*State Route 14 and Pennsylvania Route 51, Youngstown, Ohio to Pittsburgh, Pennsylvania
*U.S. Route 30, Pittsburgh to Chambersburg, Pennsylvania
*U.S. Route 11, Chambersburg to Harrisburg, Pennsylvania
*U.S. Route 322, Harrisburg to Downingtown, Pennsylvania
*U.S. Route 30, Downingtown to Philadelphia, Pennsylvania

;Interstate 580 (California)
*U.S. Route 50, Oakland to Tracy
*State Route 33 around Tracy, California

The above segment was originally designated as Interstate 5W.
*State Route 17 Oakland to San Rafael (later addition)

;Interstate 81
*U.S. Route 11, east of Knoxville, Tennessee to Harrisburg, Pennsylvania
*New route, Harrisburg to Scranton, Pennsylvania
*U.S. Route 11, Scranton to Watertown, New York
*New York State Route 180, Watertown to north of Clayton, New York

;Interstate 81E (now Interstate 380)
*U.S. Route 611, Stroudsburg, Pennsylvania to Scranton, Pennsylvania

;Interstate 82
*U.S. Route 97, Ellensburg, Washington to Toppenish, Washington
*U.S. Route 410, Toppenish to Pasco, Washington
*U.S. Route 395, Pasco to Hermiston, Oregon

;Interstate 83
*U.S. Route 111, Baltimore, Maryland to Harrisburg, Pennsylvania

;Interstate 84
*U.S. Route 6, Scranton, Pennsylvania to Hartford, Connecticut
*Route 15 (Connecticut) and Route 15 (Massachusetts), Hartford to Sturbridge, Massachusetts

;Interstate 84
*U.S. Route 20, Ontario, Oregon to Mountain Home, Idaho
*U.S. Route 26, Ontario, Oregon to Bliss, Idaho
*U.S. Route 30, Portland, Oregon to Junction with Interstate 86

;Interstate 85
*U.S. Route 80, Montgomery, Alabama to Tuskegee, Alabama
*U.S. Route 29, Tuskegee to Greensboro, North Carolina
*U.S. Route 70, Greensboro to Durham, North Carolina
*U.S. Route 15, Durham to Oxford, North Carolina
*U.S. Route 158, Oxford to Henderson, North Carolina
*U.S. Route 1, Henderson to Petersburg, Virginia

;Interstate 86
*Pennsylvania Route 17 and New York State Route 17, Erie, Pennsylvania to Harriman, New York (later addition)

;Interstate 87
*U.S. Route 9 and U.S. Route 9W, New York, New York to Albany, New York
*U.S. Route 9, Albany to Champlain, New York

;Interstate 88 (east)
*New York State Route 7, Binghamton, New York to Schenectady, New York (later addition)

;Interstate 88 (west)
*Illinois State Route 5, Quad Cities to Sterling, Illinois (later addition)
*U.S. Route 30, Sterling to Aurora, Illinois (later addition)
*U.S. Route 34, Aurora to Chicago, Illinois (later addition)

;Interstate 89
*U.S. Route 4, Concord, New Hampshire to White River Junction, Vermont
*Vermont Route 14, White River Junction to Montpelier, Vermont
*U.S. Route 2, Montpelier to Burlington, Vermont
*U.S. Route 7, Burlington to north of St. Albans, Vermont

;Interstate 90
*U.S. Route 10, Seattle, Washington to Billings, Montana
*U.S. Route 87, Billings to Buffalo, Wyoming
*U.S. Route 14, Buffalo to Rapid City, South Dakota
*U.S. Route 16, Rapid City to Portage, Wisconsin
*U.S. Route 51, Portage to Rockford, Illinois
*U.S. Route 20, Rockford to Boston, Massachusetts

;Interstate 91
*U.S. Route 5, New Haven, Connecticut to Canada

;Interstate 93
*U.S. Route 3, Boston, Massachusetts to Littleton, New Hampshire
*New Hampshire Route 18 and Vermont Route 18, Littleton to St. Johnsbury, Vermont

;Interstate 94
*U.S. Route 10, Billings, Montana to Fargo, North Dakota
*U.S. Route 52, Fargo to Minneapolis-St. Paul, Minnesota
*U.S. Route 12, Minneapolis-St. Paul to Madison, Wisconsin
*U.S. Route 18, Madison to Milwaukee, Wisconsin
*U.S. Route 41, Milwaukee to Chicago, Illinois
*U.S. Route 12, Chicago to Detroit, Michigan
*U.S. Route 25, Detroit to Canada

;Interstate 95
*U.S. Route 1, Miami, Florida to Jacksonville, Florida
*U.S. Route 17, Jacksonville to Walterboro, South Carolina
*U.S. Route 15, Walterboro to Summerton, South Carolina
*U.S. Route 301, Summerton to Petersburg, Virginia
*U.S. Route 1, Petersburg to Baltimore, Maryland
*U.S. Route 40, Baltimore to Wilmington, Delaware
*U.S. Route 13, Wilmington to Trenton, New Jersey
*U.S. Route 1, Trenton to Brunswick, Maine
*U.S. Route 201, Brunswick to Waterville, Maine
*State Route 11, Waterville to Newport, Maine
*U.S. Route 2, Newport to Houlton, Maine

;Interstate 195 (Massachusetts)
*U.S. Route 6, Providence, Rhode Island to New Bedford, Massachusetts

;Interstate 96 (now partly Interstate 196)
*U.S. Route 31, Benton Harbor, Michigan to Holland, Michigan
*M-21, Holland to Grand Rapids, Michigan
*U.S. Route 16, Grand Rapids to Detroit, Michigan

;Interstate 196 (now Interstate 96)
*U.S. Route 16, Muskegon, Michigan to Grand Rapids, Michigan

;Interstate 97
*Maryland Route 178 and Maryland Route 3, Annapolis, Maryland to Baltimore, Maryland (later addition)

;Interstate 99
*U.S. Route 220, Bedford, Pennsylvania to State College, Pennsylvania (later addition)

References

*Esso, United States Featuring The Interstate Highway System, copyright 1964 by General Drafting Company, issued April 1964 by Humble Oil and Refining Company