Nucleolar protein, member A1

Nucleolar protein, member A1
GAR1 ribonucleoprotein homolog (yeast)
Identifiers
Symbols GAR1; GAR1
External IDs OMIM606468 MGI1930948 HomoloGene6104 GeneCards: GAR1 Gene
RNA expression pattern
PBB GE NOLA1 219110 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54433 68147
Ensembl ENSG00000109534 ENSMUSG00000028010
UniProt Q9NY12 Q3TKG5
RefSeq (mRNA) NM_018983.3 NM_026578.3
RefSeq (protein) NP_061856.1 NP_080854.1
Location (UCSC) Chr 4:
110.74 – 110.75 Mb
Chr 3:
129.53 – 129.53 Mb
PubMed search [1] [2]

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.[1][2]

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.[2]

Interactions

Nucleolar protein, member A1 has been shown to interact with SMN1.[3]

References

  1. ^ Dragon F, Pogacic V, Filipowicz W (May 2000). "In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs". Mol Cell Biol 20 (9): 3037–48. doi:10.1128/MCB.20.9.3037-3048.2000. PMC 85579. PMID 10757788. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85579. 
  2. ^ a b "Entrez Gene: NOLA1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54433. 
  3. ^ Pellizzoni, L; Baccon J, Charroux B, Dreyfuss G (Jul. 2001). "The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1". Curr. Biol. (England) 11 (14): 1079–88. doi:10.1016/S0960-9822(01)00316-5. ISSN 0960-9822. PMID 11509230. 

Further reading


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