Nucleolar protein, member A1

GAR1 ribonucleoprotein homolog (yeast)
Identifiers
Symbols	GAR1; GAR1
External IDs	OMIM: 606468 MGI: 1930948 HomoloGene: 6104 GeneCards: GAR1 Gene
Gene Ontology Molecular function • cation channel activity • pseudouridine synthase activity • snoRNA binding Cellular component • nucleus • nucleolus • Cajal body • ribonucleoprotein complex • box H/ACA snoRNP complex Biological process • rRNA processing • snRNA pseudouridine synthesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54433	68147
Ensembl	ENSG00000109534	ENSMUSG00000028010
UniProt	Q9NY12	Q3TKG5
RefSeq (mRNA)	NM_018983.3	NM_026578.3
RefSeq (protein)	NP_061856.1	NP_080854.1
Location (UCSC)	Chr 4: 110.74 – 110.75 Mb	Chr 3: 129.53 – 129.53 Mb
PubMed search	[1]	[2]

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.^[1][2]

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.^[2]

Interactions

Nucleolar protein, member A1 has been shown to interact with SMN1.^[3]

References

1. ^ Dragon F, Pogacic V, Filipowicz W (May 2000). "In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs". Mol Cell Biol 20 (9): 3037–48. doi:10.1128/MCB.20.9.3037-3048.2000. PMC 85579. PMID 10757788. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85579. 
2. ^ ^{a b} "Entrez Gene: NOLA1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54433. 
3. ^ Pellizzoni, L; Baccon J, Charroux B, Dreyfuss G (Jul. 2001). "The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1". Curr. Biol. (England) 11 (14): 1079–88. doi:10.1016/S0960-9822(01)00316-5. ISSN 0960-9822. PMID 11509230. 

Further reading

• Fujii Y, Zhao FX, Fu SC, et al. (1992). "Stable preparation of aldose reductase isoenzymes from human placenta.". Protein Expr. Purif. 2 (5-6): 420–5. doi:10.1016/1046-5928(91)90103-P. PMID 1821816. 
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence." (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• Ardell MD, Aragon I, Oliveira L, et al. (1996). "The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit.". FEBS Lett. 389 (2): 213–8. doi:10.1016/0014-5793(96)00588-1. PMID 8766832. 
• Pogacić V, Dragon F, Filipowicz W (2000). "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10.". Mol. Cell. Biol. 20 (23): 9028–40. doi:10.1128/MCB.20.23.9028-9040.2000. PMC 86556. PMID 11074001. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86556. 
• Pellizzoni L, Baccon J, Charroux B, Dreyfuss G (2001). "The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1.". Curr. Biol. 11 (14): 1079–88. doi:10.1016/S0960-9822(01)00316-5. PMID 11509230. 
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
• Whitehead SE, Jones KW, Zhang X, et al. (2003). "Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1.". J. Biol. Chem. 277 (50): 48087–93. doi:10.1074/jbc.M204551200. PMID 12244096. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wang C, Meier UT (2005). "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins.". EMBO J. 23 (8): 1857–67. doi:10.1038/sj.emboj.7600181. PMC 394235. PMID 15044956. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394235. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.