Small nucleolar RNA SNORD73

snoRNA U73 (also known as SNORD73) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-ribose methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA) [cite journal | last = Rebane | first = A | coauthors = Tamme R, Laan M, Pata I, Metspalu A | year = 1998 | title = A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes | journal = Gene | volume = 210 | pages = 255–263 | pmid = 9573378 | doi = 10.1016/S0378-1119(98)00070-5 ] . U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA [cite journal | last = Rebane | first = A | coauthors = Roomere H, Metspalu A. | year = 2002 | title = Locations of several novel 2'-O-methylated nucleotides in human 28S rRNA | journal = BMC Mol Biol. | volume = 3 | pmid = 11897011 | doi = 10.1186/1471-2199-3-1 | pages = 1 ] .

References

External links

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* [http://www-snorna.biotoul.fr/plus.php?id=U73a snoRNABase entry for SNORD73A]
* [http://www-snorna.biotoul.fr/plus.php?id=U73b snoRNABase entry for SNORD73B]