Small nucleolar RNA SNORD36

snoRNA U36 (also known as SNORD36) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U36 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-ribose methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

U36 is encoded within the intron of ribosomal protein rpL7a, and has two regions of complementarity to 18S and 28S ribosomal RNA. This complementarity suggests that U36 acts as a 2'-O-ribose methylation guide cite journal | author = Nicoloso M, Qu LH, Michot B, Bachellerie JP | title = Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs | journal = J. Mol. Biol. | volume = 260 | issue = 2 | pages = 178–95 | year = 1996 | pmid = 8764399 | doi = 10.1006/jmbi.1996.0391 | issn = ] cite journal | author = Gilley J, Fried M | title = Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants | journal = DNA Cell Biol. | volume = 17 | issue = 7 | pages = 591–602 | year = 1998 | pmid = 9703018 | doi = | issn = ] . This snoRNA is also related to other snoRNAs (snoR47 and Z100) identified in the rice plant "Oryza sativa" cite journal | author = Gilley J, Fried M | title = Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants | journal = DNA Cell Biol. | volume = 17 | issue = 7 | pages = 591–602 | year = 1998 | pmid = 9703018 | doi = | issn = ] cite journal | author = Liang D, Zhou H, Zhang P, "et al" | title = A novel gene organization: intronic snoRNA gene clusters from Oryza sativa | journal = Nucleic Acids Res. | volume = 30 | issue = 14 | pages = 3262–72 | year = 2002 | pmid = 12136108 | doi = | issn = ] .

References

External links

*
* [http://www-snorna.biotoul.fr/plus.php?id=U36A snoRNABase entry for SNORD36A]
* [http://www-snorna.biotoul.fr/plus.php?id=U36A snoRNABase entry for SNORD36B]
* [http://www-snorna.biotoul.fr/plus.php?id=U36A snoRNABase entry for SNORD36C]