Malate—CoA ligase

malate-CoA ligase
Identifiers
EC number	6.2.1.9
CAS number	37318-58-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a malate-CoA ligase (EC 6.2.1.9) is an enzyme that catalyzes the chemical reaction

ATP + malate + CoA $\rightleftharpoons$ ADP + phosphate + malyl-CoA

The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

• Mue S, Tuboi S and Kikuchi G (December 1964). "On malyl-coenzyme A synthetase". J. Biochem. 56: 545–551. PMID 14244056. 

This ligase article is a stub. You can help Wikipedia by expanding it.v · Categories: Ligase stubs EC 6.2.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Malate Malatesta (film) Look at other dictionaries: Malate-CoA ligase — In enzymology, a malate CoA ligase (EC number|6.2.1.9) is an enzyme that catalyzes the chemical reaction:ATP + malate + CoA ightleftharpoons ADP + phosphate + malyl CoAThe 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3… …   Wikipedia Propionyl-CoA carboxylase — PCCA redirects here. For other uses, see PCCA (disambiguation). Propionyl CoA carboxylase Identifiers EC number 6.4.1.3 CAS number …   Wikipedia List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia Thiokinase — can refer to: * Acetate CoA ligase (ADP forming) * Butyrate CoA ligase * Citrate CoA ligase * Malate CoA ligase * Succinate CoA ligase (ADP forming) * Succinate CoA ligase (GDP forming) …   Wikipedia Enzyme — A protein (or protein based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, convertingt a specific set of reactants (called substrates) into specific products. Without …   Medical dictionary Citric acid cycle — Overview of the citric acid cycle The citric acid cycle also known as the tricarboxylic acid cycle (TCA cycle), the Krebs cycle, or the Szent Györgyi Krebs cycle[1] …   Wikipedia Pyruvate carboxylase — Protein Name=PAGENAME caption= Symbol=PC AltSymbols= HGNCid=8636 Chromosome=11 Arm=q Band=11 LocusSupplementaryData= q13.1 ECnumber=6.4.1.1 OMIM=608786 EntrezGene=5091 RefSeq=NM 000920 UniProt=P11498 PDB=Pyruvate carboxylase is an enzyme of the… …   Wikipedia metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium Citrate synthase — Identifiers Symbol CS Entrez 1431 HUGO …   Wikipedia List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”