Citrate—CoA ligase

citrate-CoA ligase
Identifiers
EC number	6.2.1.18
CAS number	856428-87-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a citrate-CoA ligase (EC 6.2.1.18) is an enzyme that catalyzes the chemical reaction

ATP + citrate + CoA $\rightleftharpoons$ ADP + phosphate + (3S)-citryl-CoA

The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates in citric acid cycle.

References

• Lill U, Schreil A, Eggerer H (1982). "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125 (3): 645–50. doi:10.1111/j.1432-1033.1982.tb06731.x. PMID 6749502. 
• Aoshima M, Ishii M, Igarashi Y (2004). "A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 52 (3): 751–61. doi:10.1111/j.1365-2958.2004.04009.x. PMID 15101981. 

This ligase article is a stub. You can help Wikipedia by expanding it.v · Categories: Ligase stubs EC 6.2.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Citrangequat Citrate test Look at other dictionaries: Citrate-CoA ligase — In enzymology, a citrate CoA ligase (EC number|6.2.1.18) is an enzyme that catalyzes the chemical reaction:ATP + citrate + CoA ightleftharpoons ADP + phosphate + (3S) citryl CoAThe 3 substrates of this enzyme are ATP, citrate, and CoA, whereas… …   Wikipedia Succinate-CoA ligase (ADP-forming) — In enzymology, a succinate CoA ligase (ADP forming) (EC number|6.2.1.5) is an enzyme that catalyzes the chemical reaction:ATP + succinate + CoA ightleftharpoons ADP + phosphate + succinyl CoAThe 3 substrates of this enzyme are ATP, succinate, and …   Wikipedia Succinate-CoA ligase (GDP-forming) — In enzymology, a succinate CoA ligase (GDP forming) (EC number|6.2.1.4) is an enzyme that catalyzes the chemical reaction:GTP + succinate + CoA ightleftharpoons GDP + phosphate + succinyl CoAThe 3 substrates of this enzyme are GTP, succinate, and …   Wikipedia Citrate synthase — Identifiers Symbol CS Entrez 1431 HUGO …   Wikipedia Propionyl-CoA carboxylase — PCCA redirects here. For other uses, see PCCA (disambiguation). Propionyl CoA carboxylase Identifiers EC number 6.4.1.3 CAS number …   Wikipedia acetyl-CoA carboxylase — ac·e·tyl CoA car·box·yl·ase (asґə təl ) (as″ə tēlґko aґ kahr bokґsə lās) [EC 6.4.1.2] a biotin containing enzyme of the ligase class that catalyzes the carboxylation of acetyl coenzyme A to form malonyl… …   Medical dictionary List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia Thiokinase — can refer to: * Acetate CoA ligase (ADP forming) * Butyrate CoA ligase * Citrate CoA ligase * Malate CoA ligase * Succinate CoA ligase (ADP forming) * Succinate CoA ligase (GDP forming) …   Wikipedia Citric acid cycle — Overview of the citric acid cycle The citric acid cycle also known as the tricarboxylic acid cycle (TCA cycle), the Krebs cycle, or the Szent Györgyi Krebs cycle[1] …   Wikipedia Enzyme — A protein (or protein based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, convertingt a specific set of reactants (called substrates) into specific products. Without …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”