- Succinate-CoA ligase (ADP-forming)
enzymology, a succinate-CoA ligase (ADP-forming) (EC number|188.8.131.52) is an enzymethat catalyzes the chemical reaction
:ATP + succinate + CoA ADP + phosphate + succinyl-CoA
The 3 substrates of this enzyme are ATP,
succinate, and CoA, whereas its 3 products are ADP, phosphate, and succinyl-CoA.
This enzyme belongs to the family of
ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (ADP-forming). Other names in common use include succinyl-CoA synthetase (ADP-forming), succinic thiokinase, succinate thiokinase, succinyl-CoA synthetase, succinyl coenzyme A synthetase (adenosine diphosphate-forming), succinyl coenzyme A synthetase, A-STK (adenin nucleotide-linked succinate thiokinase), STK, and A-SCS. This enzyme participates in 4 metabolic pathways: citrate cycle (tca cycle), propanoate metabolism, c5-branched dibasic acid metabolism, and reductive carboxylate cycle (co2 fixation).
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CQI, PDB link|1CQJ, PDB link|1JKJ, PDB link|1JLL, PDB link|1OI7, PDB link|1SCU, PDB link|2NU6, PDB link|2NU7, PDB link|2NU8, PDB link|2NU9, PDB link|2NUA, and PDB link|2SCU.
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
CAS registry numberfor this enzyme class is CAS registry|9080-33-5."
Gene Ontology (GO) codes
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