Succinate-CoA ligase (ADP-forming)

In enzymology, a succinate-CoA ligase (ADP-forming) (EC number|6.2.1.5) is an enzyme that catalyzes the chemical reaction

:ATP + succinate + CoA $ightleftharpoons$ ADP + phosphate + succinyl-CoA

The 3 substrates of this enzyme are ATP, succinate, and CoA, whereas its 3 products are ADP, phosphate, and succinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (ADP-forming). Other names in common use include succinyl-CoA synthetase (ADP-forming), succinic thiokinase, succinate thiokinase, succinyl-CoA synthetase, succinyl coenzyme A synthetase (adenosine diphosphate-forming), succinyl coenzyme A synthetase, A-STK (adenin nucleotide-linked succinate thiokinase), STK, and A-SCS. This enzyme participates in 4 metabolic pathways: citrate cycle (tca cycle), propanoate metabolism, c5-branched dibasic acid metabolism, and reductive carboxylate cycle (co2 fixation).

tructural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CQI, PDB link|1CQJ, PDB link|1JKJ, PDB link|1JLL, PDB link|1OI7, PDB link|1SCU, PDB link|2NU6, PDB link|2NU7, PDB link|2NU8, PDB link|2NU9, PDB link|2NUA, and PDB link|2SCU.

References

* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9080-33-5."

Gene Ontology (GO) codes