Succinate-CoA ligase (GDP-forming)

In enzymology, a succinate-CoA ligase (GDP-forming) (EC number|6.2.1.4) is an enzyme that catalyzes the chemical reaction

:GTP + succinate + CoA $ightleftharpoons$ GDP + phosphate + succinyl-CoA

The 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (GDP-forming). Other names in common use include succinyl-CoA synthetase (GDP-forming), succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinate thiokinase, succinic thiokinase, succinyl coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, and succinyl coenzyme A synthetase. This enzyme participates in citrate cycle (tca cycle) and propanoate metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EUC, PDB link|1EUD, PDB link|2FP4, PDB link|2FPG, PDB link|2FPI, and PDB link|2FPP.

References

* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9014-36-2."

Gene Ontology (GO) codes