4-Chloromercuribenzoic acid

4-Chloromercuribenzoic acid
4-Chloromercuribenzoic acid[1]
Identifiers
Abbreviations PCMB
CAS number 59-85-8 YesY
PubChem 1730
ChemSpider 1667 YesY
ChEBI CHEBI:28420 N
ChEMBL CHEMBL575867 N
Jmol-3D images Image 1
Properties
Molecular formula C7H5ClHgO2
Molar mass 357.16 g mol−1
Melting point

287 °C (dec.)

Hazards
R-phrases R26/27/28 R33 R50/53
S-phrases S13 S28 S36 S45 S60 S61
 N acid (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

4-Chloromercuribenzoic acid (p-chloromercuribenzoic acid, PCMB) is an organomercury compound that is used as a protease inhibitor, especially in molecular biology applications.

PCMB reacts with thiol groups in proteins and is therefore an inhibitor of enzymes that are dependent on thiol reactivity, including cysteine proteases such as papain and acetylcholinesterase. Because of this reactivity with thiols, PCMB is also used in titrimetric quantification of thiol groups in proteins.

References


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Look at other dictionaries:

  • 4-Chlormercuribenzoesäure — Strukturformel Allgemeines Name 4 Chlormercuribenzoesäure Andere Namen …   Deutsch Wikipedia

  • PCMB — may refer to: p Chloromercuribenzoic acid Plymouth Canton Marching Band This disambiguation page lists articles associated with the same title. If an internal link led you here, you may wish to change the link to point directly …   Wikipedia

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