Benzthiazide

Benzthiazide

Systematic (IUPAC) name
6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Bioavailability	60 to 70%
Protein binding	30%
Half-life	5 to 15 hours
Excretion	Renal
Identifiers
CAS number	91-33-8 Y
ATC code	None
PubChem	CID 2343
DrugBank	DB00562
ChemSpider	2253 Y
UNII	1TD8J48L61 Y
KEGG	D00651 Y
ChEBI	CHEBI:3047 Y
ChEMBL	CHEMBL1201039 N
Chemical data
Formula	C15H14ClN3O4S3
Mol. mass	431.94 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21) Y Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N Y
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Benzthiazide (BAN/INN, also known as benzothiazide; trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others^[1]) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States.

In the United Kingdom, it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide.^[2] The same combination is still available in Switzerland as Dyrenium compositum.^[3]

References

1. ^ David J. Triggle; C. R. Ganellin, F. MacDonald (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC. pp. p. 246. ISBN 0-412-46630-9. http://books.google.com/books?id=DeX7jgInYFMC&printsec=frontcover&source=gbs_summary_r&cad=0#PRA1-PA711,M1.  Retrieved on August 29, 2008 through Google Book Search.
2. ^ "Triamterene and Benzthiazide". PatientUK. 2005. http://www.patient.co.uk/showdoc/30002902. Retrieved 2008-08-29. 
3. ^ "Dyrenium compositum". Doetsch Grether. n.d.. http://www.doetschgrether.ch/de/Dyrenium_Detail.asp. Retrieved 2008-08-29. ^{[dead link]}