Malate dehydrogenase 2

Malate dehydrogenase 2, NAD (mitochondrial)
PDB rendering based on 1mld.
Available structures PDB 1mld, 2dfd
Identifiers
Symbols	MDH2; M-MDH; MDH; MGC:3559; MOR1
External IDs	OMIM: 154100 MGI: 97050 HomoloGene: 55938 GeneCards: MDH2 Gene
EC number	1.1.1.37
Gene Ontology Molecular function • binding • oxidoreductase activity • L-malate dehydrogenase activity • L-malate dehydrogenase activity • L-malate dehydrogenase activity Cellular component • nucleus • nucleolus • mitochondrion • mitochondrial inner membrane • mitochondrial matrix • plasma membrane Biological process • carbohydrate metabolic process • glucose metabolic process • gluconeogenesis • tricarboxylic acid cycle • malate metabolic process • malate metabolic process • cellular carbohydrate metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4191	17448
Ensembl	ENSG00000146701	ENSMUSG00000019179
UniProt	P40926	Q0QF44
RefSeq (mRNA)	NM_005918	NM_008617.2
RefSeq (protein)	NP_005909	NP_032643.2
Location (UCSC)	Chr 7: 75.68 – 75.7 Mb	Chr 5: 136.25 – 136.27 Mb
PubMed search	[1]	[2]

Malate dehydrogenase 2, NAD (mitochondrial), also known as MDH2, is a protein which in humans is encoded by the MDH2 gene.^[1]

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^[3]

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Citric_acid_cycle edit

See also

• Malate dehydrogenase

References

1. ^ Habets GG, van der Kammen RA, Willemsen V, Balemans M, Wiegant J, Collard JG (1992). "Sublocalization of an invasion-inducing locus and other genes on human chromosome 7". Cytogenet. Cell Genet. 60 (3–4): 200–5. doi:10.1159/000133336. PMID 1505215. 
2. ^ "Entrez Gene: MDH2 malate dehydrogenase 2, NAD (mitochondrial)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4191. 
3. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". http://www.wikipathways.org/index.php/Pathway:WP78.