Malate dehydrogenase (NADP+)

malate dehydrogenase (NADP+)
Identifiers
EC number	1.1.1.82
CAS number	37250-19-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a malate dehydrogenase (NADP+) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction

(S)-malate + NADP⁺ $\rightleftharpoons$ oxaloacetate + NADPH + H⁺

Thus, the two substrates of this enzyme are (S)-malate and NADP⁺, whereas its 3 products are oxaloacetate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase. Other names in common use include NADP+-malic enzyme, NADP+-malate dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), malate NADP+ dehydrogenase, NADP+ malate dehydrogenase, NADP+-linked malate dehydrogenase, and malate dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism and carbon fixation. This enzyme has at least one effector, hn.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CIV and 7MDH.

References

• Connelly JL, Danner DJ, Bowden JA (1968). "Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase". J. Biol. Chem. 243 (6): 1198–203. PMID 5689906. 
• Johnson HS (1971). "NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis". Biochem. Biophys. Res. Commun. 43 (4): 703–9. doi:10.1016/0006-291X(71)90672-3. PMID 4397919. 
• Johnson HS, Hatch MD (1970). "Properties and regulation of leaf nicotinamide–adenine dinucleotide phosphate–malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis". Biochem. J. 119 (2): 273–80. PMC 1179348. PMID 4395182. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1179348. 

This EC 1.1.1 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 1.1.1 stubs EC 1.1.1 NADPH-dependent enzymes Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Calinaoan Malate dehydrogenase (oxaloacetate-decarboxylating) Look at other dictionaries: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) — Identifiers EC number 1.1.1.40 CAS number 9028 47 1 …   Wikipedia Malate dehydrogenase — Structure of the protein with attached sugars Identifiers EC number …   Wikipedia Malate dehydrogenase (oxaloacetate-decarboxylating) — Identifiers EC number 1.1.1.38 CAS number 9080 52 8 …   Wikipedia Malate dehydrogenase (decarboxylating) — Malic Enzyme (decarboxylating) Identifiers EC number 1.1.1.39 CAS number 9028 46 0 …   Wikipedia malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) — ma·late de·hy·dro·gen·ase (ox·alo·ac·e·tate de·car·box·y·lat·ing) (NADP+) (maґlāt de hiґdro jən ās ok sal″o asґə tāt de kahr bokґsə lāt″ing) an enzyme of the oxidoreductase class that catalyzes the… …   Medical dictionary D-malate dehydrogenase (decarboxylating) — Identifiers EC number 1.1.1.83 CAS number 37250 20 7 …   Wikipedia Dehydrogenase — A dehydrogenase (also called DHO in the literature) is an enzyme that oxidises a substrate by a reduction reaction that transfers one or more hydrides (H−) to an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN.… …   Wikipedia malate — A salt or ester of malic acid. m. dehydrogenase an enzyme that catalyzes, through NAD+ or NADP+, the dehydrogenation of m. to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six m. dehydrogenases are known, distinguished by… …   Medical dictionary Succinate dehydrogenase — (ubiquinone) Subunits: SdhA, SdhB, SdhC and SdhD Identifiers EC number …   Wikipedia NADH dehydrogenase — Structure of NADH dehydrogenase Identifiers EC number 1.6.5.3 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”