- D-malate dehydrogenase (decarboxylating)
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D-malate dehydrogenase (decarboxylating) Identifiers EC number 1.1.1.83 CAS number 37250-20-7 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a D-malate dehydrogenase (decarboxylating) (EC 1.1.1.83) is an enzyme that catalyzes the chemical reaction
- (R)-malate + NAD+
pyruvate + CO2 + NADH
Thus, the two substrates of this enzyme are (R)-malate and NAD+, whereas its 3 products are pyruvate, CO2, and NADH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-malate:NAD+ oxidoreductase (decarboxylating). Other names in common use include D-malate dehydrogenase, D-malic enzyme, bifunctional L(+)-tartrate dehydrogenase-D(+)-malate, and (decarboxylating). This enzyme participates in butanoate metabolism.
References
- Stern JR, O'Brien RW (1969). "Oxidation of d-Malic and β-Alkylmalic Acids by Wild-Type and Mutant Strains of Salmonella typhimurium and by Aerobacter aerogenes". J. Bacteriol. 98 (1): 147–51. PMC 249916. PMID 4889267. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=249916.
This EC 1.1.1 enzyme-related article is a stub. You can help Wikipedia by expanding it. - (R)-malate + NAD+
