DOC2A

Double C2-like domains, alpha
Identifiers
Symbols	DOC2A;
External IDs	OMIM: 604567 MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A Gene
Gene Ontology Molecular function • transporter activity • binding • protein binding • calcium-dependent phospholipid binding Cellular component • lysosome • membrane • synaptosome • cell junction • synaptic vesicle membrane • cytoplasmic vesicle • synapse Biological process • synaptic transmission • nervous system development • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8448	13446
Ensembl	ENSG00000149927	ENSMUSG00000052301
UniProt	Q14183	O35527
RefSeq (mRNA)	NM_003586	NM_010069.1
RefSeq (protein)	NP_003577	NP_034199.1
Location (UCSC)	Chr 16: 30.02 – 30.02 Mb	Chr 7: 133.99 – 134 Mb
PubMed search	[1]	[2]

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.^[1][2][3]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.^[3]

Interactions

DOC2A has been shown to interact with UNC13B.^[4][2]

References

1. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360. 
2. ^ ^{a b} Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21657. 
3. ^ ^{a b} "Entrez Gene: DOC2A double C2-like domains, alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8448. 
4. ^ Orita, S; Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (Jun. 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. (UNITED STATES) 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. ISSN 0021-9258. PMID 9195900. 

Further reading

• Sakaguchi G, Orita S, Maeda M et al. (1996). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557. 
• Verhage M, de Vries KJ, Røshol H et al. (1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738. 
• Orita S, Naito A, Sakaguchi G et al. (1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900. 
• Nagano F, Orita S, Sasaki T et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.