UNC13B

Unc-13 homolog B (C. elegans), also known as UNC13B, is a human gene.cite web | title = Entrez Gene: UNC13B unc-13 homolog B (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10497| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.cite web | title = Entrez Gene: UNC13B unc-13 homolog B (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10497| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Betz A, Okamoto M, Benseler F, Brose N |title=Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2520–6 |year= 1997 |pmid= 8999968 |doi=
*cite journal | author=Orita S, Naito A, Sakaguchi G, "et al." |title=Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16081–4 |year= 1997 |pmid= 9195900 |doi=
*cite journal | author=Song Y, Ailenberg M, Silverman M |title=Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy. |journal=Kidney Int. |volume=53 |issue= 6 |pages= 1689–95 |year= 1998 |pmid= 9607201 |doi= 10.1046/j.1523-1755.1998.00942.x
*cite journal | author=Sakaguchi G, Orita S, Naito A, "et al." |title=A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 846–51 |year= 1998 |pmid= 9704016 |doi= 10.1006/bbrc.1998.9067
*cite journal | author=Mochida S, Orita S, Sakaguchi G, "et al." |title=Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11418–22 |year= 1998 |pmid= 9736751 |doi=
*cite journal | author=Song Y, Ailenberg M, Silverman M |title=Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia. |journal=Mol. Biol. Cell |volume=10 |issue= 5 |pages= 1609–19 |year= 1999 |pmid= 10233166 |doi=
*cite journal | author=Duncan RR, Betz A, Shipston MJ, "et al." |title=Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27347–50 |year= 1999 |pmid= 10488064 |doi=
*cite journal | author=Betz A, Thakur P, Junge HJ, "et al." |title=Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. |journal=Neuron |volume=30 |issue= 1 |pages= 183–96 |year= 2001 |pmid= 11343654 |doi=
*cite journal | author=Schoch S, Castillo PE, Jo T, "et al." |title=RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. |journal=Nature |volume=415 |issue= 6869 |pages= 321–6 |year= 2002 |pmid= 11797009 |doi= 10.1038/415321a
*cite journal | author=Ohtsuka T, Takao-Rikitsu E, Inoue E, "et al." |title=Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. |journal=J. Cell Biol. |volume=158 |issue= 3 |pages= 577–90 |year= 2002 |pmid= 12163476 |doi= 10.1083/jcb.200202083
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sheu L, Pasyk EA, Ji J, "et al." |title=Regulation of insulin exocytosis by Munc13-1. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27556–63 |year= 2003 |pmid= 12871971 |doi= 10.1074/jbc.M303203200
*cite journal | author=Cheviet S, Coppola T, Haynes LP, "et al." |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. |journal=Mol. Endocrinol. |volume=18 |issue= 1 |pages= 117–26 |year= 2004 |pmid= 14593078 |doi= 10.1210/me.2003-0300
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Yamamoto K, Ishii E, Sako M, "et al." |title=Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 763–7 |year= 2005 |pmid= 15466010 |doi= 10.1136/jmg.2004.021121
*cite journal | author=Speight P, Silverman M |title=Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34. |journal=Traffic |volume=6 |issue= 10 |pages= 858–65 |year= 2005 |pmid= 16138900 |doi= 10.1111/j.1600-0854.2005.00321.x

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