WFDC2

WAP four-disulfide core domain 2, also known as WFDC2, is a human gene.cite web | title = Entrez Gene: WFDC2 WAP four-disulfide core domain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10406| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.cite web | title = Entrez Gene: WFDC2 WAP four-disulfide core domain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10406| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kirchhoff C |title=Molecular characterization of epididymal proteins. |journal=Rev. Reprod. |volume=3 |issue= 2 |pages= 86–95 |year= 1998 |pmid= 9685187 |doi=
*cite journal | author=Kirchhoff C, Habben I, Ivell R, Krull N |title=A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. |journal=Biol. Reprod. |volume=45 |issue= 2 |pages= 350–7 |year= 1992 |pmid= 1686187 |doi=
*cite journal | author=Kirchhoff C, Osterhoff C, Habben I, "et al." |title=Cloning and analysis of mRNAs expressed specifically in the human epididymis. |journal=Int. J. Androl. |volume=13 |issue= 2 |pages= 155–67 |year= 1990 |pmid= 1693137 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Schummer M, Ng WV, Bumgarner RE, "et al." |title=Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. |journal=Gene |volume=238 |issue= 2 |pages= 375–85 |year= 1999 |pmid= 10570965 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Bingle L, Singleton V, Bingle CD |title=The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. |journal=Oncogene |volume=21 |issue= 17 |pages= 2768–73 |year= 2002 |pmid= 11965550 |doi= 10.1038/sj.onc.1205363
*cite journal | author=Clauss A, Lilja H, Lundwall A |title=A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 233–42 |year= 2002 |pmid= 12206714 |doi= 10.1042/BJ20020869
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hellström I, Raycraft J, Hayden-Ledbetter M, "et al." |title=The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3695–700 |year= 2003 |pmid= 12839961 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Drapkin R, von Horsten HH, Lin Y, "et al." |title=Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. |journal=Cancer Res. |volume=65 |issue= 6 |pages= 2162–9 |year= 2005 |pmid= 15781627 |doi= 10.1158/0008-5472.CAN-04-3924
*cite journal | author=Clauss A, Lilja H, Lundwall A |title=The evolution of a genetic locus encoding small serine proteinase inhibitors. |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 2 |pages= 383–9 |year= 2005 |pmid= 15950183 |doi= 10.1016/j.bbrc.2005.05.125
*cite journal | author=Bingle L, Cross SS, High AS, "et al." |title=WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. |journal=Respir. Res. |volume=7 |issue= |pages= 61 |year= 2006 |pmid= 16600032 |doi= 10.1186/1465-9921-7-61
*cite journal | author=Ramachandran P, Boontheung P, Xie Y, "et al." |title=Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. |journal=J. Proteome Res. |volume=5 |issue= 6 |pages= 1493–503 |year= 2006 |pmid= 16740002 |doi= 10.1021/pr050492k

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