Amoscanate

Amoscanate
IUPAC name 4-isothiocyanato-N-(4-nitrophenyl)aniline
Other names 4-Isothiocyanato-4′-nitrodiphenylamine Nithiocyamine
Identifiers
CAS number	26328-53-0
PubChem	33488
ChemSpider	30904 Y
ChEBI	CHEBI:38944 Y
ChEMBL	CHEMBL93385 Y
Jmol-3D images	Image 1 Image 2
SMILES O=N(=O)c1ccc(Nc2ccc(cc2)N=C=S)cc1 [O-][N+](=O)c1ccc(cc1)Nc2ccc(N=C=S)cc2
InChI InChI=1S/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H Y Key: DKVNAGXPRSYHLB-UHFFFAOYSA-N Y InChI=1/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H
Properties
Molecular formula	C13H9N3O2S
Molar mass	271.29 g mol−1
Melting point	204–206 °C
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Amoscanate (INN), also known as nithiocyamine, is an experimental anthelmintic agent of the arylisothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,^[1] and is also highly active against hookworm infection.^[2][3] However, significant liver toxicity was seen in lab animals at higher doses. The ether analogue of amoscanate, nitroscanate, is used in veterinary medicine as an anthelmintic.

Amoscanate was developed by Ciba.^[4][5]

References

1. ^ Shapiro TA, Were JB, Talalay P, et al. (September 1986). "Clinical evaluation of amoscanate in healthy male volunteers". Am. J. Trop. Med. Hyg. 35 (5): 945–53. PMID 3766854. http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=3766854. 
2. ^ Doshi JC, Vaidya AB, Sen HG, Mankodi NA, Nair CN, Grewal RS (July 1977). "Clinical trials of a new anthelmintic, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), for the cure of hookworm infection". Am. J. Trop. Med. Hyg. 26 (4): 636–9. PMID 889004. http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=889004. 
3. ^ Singh DS, Bala-Subramaniam R, Bhatia VN, Kumar V, Chandrasekar S (1981). "Study of the efficacy of compound Go.9333 (Ciba-Geigy) in hookworm infestation". Chemotherapy 27 (3): 220–3. doi:10.1159/000237981. PMID 7014129. 
4. ^ Vaidya AB, Sen HG, Mankodi NA, Paul T, Sheth UK (August 1977). "Phase 1 tolerability and searching dose studies with 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), a new anthelmintic". Br J Clin Pharmacol 4 (4): 463–7. PMC 1429051. PMID 901739. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1429051. 
5. ^ Sharma S (1987). "Helminth diseases". In Jucker E (ed.). Progress in Drug Research. 31. Boston: Birkhauser. ISBN 3-7643-1837-6. http://books.google.com/books?id=gx6dwxmlQwMC&pg=PA23&dq=amoscanate&lr=&sig=ACfU3U2tByZxa6-nDwHVl2UgdU9JYhZ1Qg.  Retrieved on September 10, 2008 through Google Book Search.

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Anthelmintics Isothiocyanates Antiinfective agent stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Christian E. Christiansen Cubworld Look at other dictionaries: amoscanate — noun An experimental anthelmintic agent of the arylisothiocyanate class, found to be highly effective in animals against hookworms and the four major species of schistosomes, but possibly hepatotoxic. Syn: nithiocyamine …   Wiktionary Genital schistosomiasis — is an infection of the genitals. Manifestations of genital schistosomiasis mucosal findings in womenMucosal grainy sandy patches seem to be pathognomonic for S. haematobium infection in the female genitals [1,2] . S. haematobium infection… …   Wikipedia nithiocyamine — noun amoscanate …   Wiktionary nitroscanate — noun The ether analogue of amoscanate, used in veterinary medicine as an anthelmintic …   Wiktionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”