NDFIP2

Nedd4 family interacting protein 2
Identifiers
Symbols	NDFIP2; FLJ25842; KIAA1165; N4WBP5A
External IDs	OMIM: 610041 MGI: 1923523 HomoloGene: 12636 GeneCards: NDFIP2 Gene
Gene Ontology Molecular function • signal transducer activity • protein binding • WW domain binding Cellular component • Golgi membrane • cytoplasm • mitochondrion • endosome • endoplasmic reticulum • Golgi apparatus • endosome membrane • membrane • integral to membrane • multivesicular body membrane • perinuclear region of cytoplasm Biological process • signal transduction • negative regulation of gene expression • positive regulation of protein ubiquitination • negative regulation of transporter activity • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54602	76273
Ensembl	ENSG00000102471	ENSMUSG00000053253
UniProt	Q9NV92	Q3KQN1
RefSeq (mRNA)	NM_001161407.1	XM_001005690
RefSeq (protein)	NP_001154879.1	XP_001005690
Location (UCSC)	Chr 13: 80.06 – 80.13 Mb	Chr 14: 105.66 – 105.71 Mb
PubMed search	[1]	[2]

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.^[1][2][3]

Interactions

NDFIP2 has been shown to interact with NEDD4.^[4]

References

1. ^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461. 
2. ^ Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem 277 (33): 29406–16. doi:10.1074/jbc.M203018200. PMID 12050153. 
3. ^ "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54602. 
4. ^ Cristillo, Anthony D; Nie Linghu, Macri Mirtha J, Bierer Barbara E (Sep. 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. (United States) 278 (36): 34587–97. doi:10.1074/jbc.M304723200. ISSN 0021-9258. PMID 12796489. 

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. 
• Cristillo AD, Nie L, Macri MJ, Bierer BE (2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes.". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. PMID 12796489. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665288. 
• Shearwin-Whyatt LM, Brown DL, Wylie FG, et al. (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.". J. Cell. Sci. 117 (Pt 16): 3679–89. doi:10.1242/jcs.01212. PMID 15252135. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.