SMURF1

SMAD specific E3 ubiquitin protein ligase 1, also known as SMURF1, is a human gene.cite web | title = Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57154| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.cite web | title = Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57154| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wrana JL, Attisano L |title=The Smad pathway. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 5–13 |year= 2000 |pmid= 10708948 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Zhu H, Kavsak P, Abdollah S, "et al." |title=A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. |journal=Nature |volume=400 |issue= 6745 |pages= 687–93 |year= 1999 |pmid= 10458166 |doi= 10.1038/23293
*cite journal | author=Nagase T, Kikuno R, Nakayama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=
*cite journal | author=Ebisawa T, Fukuchi M, Murakami G, "et al." |title=Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12477–80 |year= 2001 |pmid= 11278251 |doi= 10.1074/jbc.C100008200
*cite journal | author=Suzuki C, Murakami G, Fukuchi M, "et al." |title=Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39919–25 |year= 2002 |pmid= 12151385 |doi= 10.1074/jbc.M201901200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tajima Y, Goto K, Yoshida M, "et al." |title=Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10716–21 |year= 2003 |pmid= 12519765 |doi= 10.1074/jbc.M212663200
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Koinuma D, Shinozaki M, Komuro A, "et al." |title=Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6458–70 |year= 2004 |pmid= 14657019 |doi= 10.1093/emboj/cdg632
*cite journal | author=Wang HR, Zhang Y, Ozdamar B, "et al." |title=Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. |journal=Science |volume=302 |issue= 5651 |pages= 1775–9 |year= 2003 |pmid= 14657501 |doi= 10.1126/science.1090772
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Asano Y, Ihn H, Yamane K, "et al." |title=Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. |journal=J. Clin. Invest. |volume=113 |issue= 2 |pages= 253–64 |year= 2004 |pmid= 14722617 |doi= 10.1172/JCI200416269
*cite journal | author=Jin YH, Jeon EJ, Li QL, "et al." |title=Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29409–17 |year= 2004 |pmid= 15138260 |doi= 10.1074/jbc.M313120200
*cite journal | author=Shearwin-Whyatt LM, Brown DL, Wylie FG, "et al." |title=N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. |journal=J. Cell. Sci. |volume=117 |issue= Pt 16 |pages= 3679–89 |year= 2005 |pmid= 15252135 |doi= 10.1242/jcs.01212
*cite journal | author=Bryan B, Cai Y, Wrighton K, "et al." |title=Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth. |journal=FEBS Lett. |volume=579 |issue= 5 |pages= 1015–9 |year= 2005 |pmid= 15710384 |doi= 10.1016/j.febslet.2004.12.074
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776

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