Defensin, beta 103B

PDB rendering based on 1kj6.
Symbols DEFB103B; BD-3; DEFB103; DEFB103A; DEFB3; HBD3; HBP3
External IDs OMIM606611 MGI2675345 HomoloGene10256 GeneCards: DEFB103B Gene
Species Human Mouse
Entrez 55894 244332
Ensembl ENSG00000176797 ENSMUSG00000046354
UniProt P81534 Q14BD1
RefSeq (mRNA) NM_018661 NM_183026.2
RefSeq (protein) NP_061131 NP_898847.1
Location (UCSC) Chr 8:
7.78 – 7.78 Mb
Chr 8:
19.19 – 19.2 Mb
PubMed search [1] [2]

Beta-defensin 103 is a protein that in humans is encoded by the DEFB103A gene.[1][2][3]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.[3]


  1. ^ Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB Jr (Mar 2001). "Discovery of new human beta-defensins using a genomics-based approach". Gene 263 (1–2): 211–8. doi:10.1016/S0378-1119(00)00569-2. PMID 11223260. 
  2. ^ Harder J, Bartels J, Christophers E, Schroder JM (Feb 2001). "Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic". J Biol Chem 276 (8): 5707–13. doi:10.1074/jbc.M008557200. PMID 11085990. 
  3. ^ a b "Entrez Gene: DEFB103A defensin, beta 103A". 

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Look at other dictionaries:

  • Defensin — Monomeric and dimeric structures of human beta defensin HBD 2 Defensins are small cysteine rich cationic proteins found in both vertebrates and invertebrates. They have also been reported in plants.[1] …   Wikipedia

  • Beta defensin — Pfam box Symbol = Defensin beta Name = Beta defensin width =200 caption = Pfam= PF00711 InterPro= IPR001855 SMART= Prosite = SCOP = 1bnb TCDB = OPM family= 56 OPM protein= 1ut3 PDB=PDB3|1ijuC:33 68 PDB3|1kj5A:33 68 PDB3|1ijvB:33 68PDB3|1e4sA:33… …   Wikipedia

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