- WWP2
WW domain containing E3 ubiquitin protein ligase 2, also known as WWP2, is a human
gene .cite web | title = Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11060| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11060| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, "et al." |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611–6 |year= 1997 |pmid= 9169421 |doi=
*cite journal | author=Jonsson AB |title=Identification of a human cDNA clone that mediates adherence of pathogenic Neisseria to non-binding cells. |journal=FEMS Microbiol. Lett. |volume=162 |issue= 1 |pages= 25–30 |year= 1998 |pmid= 9595660 |doi=
*cite journal | author=Wood JD, Yuan J, Margolis RL, "et al." |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149–60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677
*cite journal | author=Winberg G, Matskova L, Chen F, "et al." |title=Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. |journal=Mol. Cell. Biol. |volume=20 |issue= 22 |pages= 8526–35 |year= 2000 |pmid= 11046148 |doi=
*cite journal | author=Harvey KF, Shearwin-Whyatt LM, Fotia A, "et al." |title=N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9307–17 |year= 2002 |pmid= 11748237 |doi= 10.1074/jbc.M110443200
*cite journal | author=McDonald FJ, Western AH, McNeil JD, "et al." |title=Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F431–6 |year= 2002 |pmid= 12167593 |doi= 10.1152/ajprenal.00080.2002
*cite journal | author=Galinier R, Gout E, Lortat-Jacob H, "et al." |title=Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14299–305 |year= 2003 |pmid= 12450395 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Shearwin-Whyatt LM, Brown DL, Wylie FG, "et al." |title=N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. |journal=J. Cell. Sci. |volume=117 |issue= Pt 16 |pages= 3679–89 |year= 2005 |pmid= 15252135 |doi= 10.1242/jcs.01212
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rougier JS, van Bemmelen MX, Bruce MC, "et al." |title=Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 3 |pages= C692–701 |year= 2005 |pmid= 15548568 |doi= 10.1152/ajpcell.00460.2004
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240PBB_Controls
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