TSPAN32

Tetraspanin 32, also known as TSPAN32, is a human gene.cite web | title = Entrez Gene: TSPAN32 tetraspanin 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10077| accessdate = ]

PBB_Summary
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summary_text = This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. This gene is described as a member of the tetraspanin superfamily. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.cite web | title = Entrez Gene: TSPAN32 tetraspanin 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10077| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Koi M, Johnson LA, Kalikin LM, "et al." |title=Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. |journal=Science |volume=260 |issue= 5106 |pages= 361–4 |year= 1993 |pmid= 8469989 |doi=
*cite journal | author=Hu RJ, Lee MP, Connors TD, "et al." |title=A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. |journal=Genomics |volume=46 |issue= 1 |pages= 9–17 |year= 1998 |pmid= 9403053 |doi= 10.1006/geno.1997.4981
*cite journal | author=Lee MP, Brandenburg S, Landes GM, "et al." |title=Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 683–90 |year= 1999 |pmid= 10072438 |doi=
*cite journal | author=Paulsen M, El-Maarri O, Engemann S, "et al." |title=Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. |journal=Hum. Mol. Genet. |volume=9 |issue= 12 |pages= 1829–41 |year= 2000 |pmid= 10915772 |doi=
*cite journal | author=Nicholson RH, Pantano S, Eliason JF, "et al." |title=Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. |journal=Genomics |volume=68 |issue= 1 |pages= 13–21 |year= 2001 |pmid= 10950922 |doi= 10.1006/geno.2000.6277
*cite journal | author=Robb L, Tarrant J, Groom J, "et al." |title=Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. |journal=Biochim. Biophys. Acta |volume=1522 |issue= 1 |pages= 31–41 |year= 2001 |pmid= 11718897 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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