Cyclin K

Cyclin K
Cyclin K

PDB rendering based on 2i53.
Identifiers
Symbols CCNK; CPR4; MGC9113
External IDs OMIM603544 HomoloGene14748 GeneCards: CCNK Gene
RNA expression pattern
PBB GE CCNK 219273 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8812 12454
Ensembl ENSG00000090061 ENSMUSG00000021258
UniProt O75909 n/a
RefSeq (mRNA) NM_003858 NM_009832.2
RefSeq (protein) NP_003849 NP_033962.2
Location (UCSC) Chr 14:
99.95 – 99.98 Mb
Chr 12:
109.42 – 109.44 Mb
PubMed search [1] [2]

Cyclin-K is a protein that in humans is encoded by the CCNK gene.[1][2][3]

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.[3]

Interactions

Cyclin K has been shown to interact with CDK9.[2]

References

  1. ^ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity". Mol Cell Biol 18 (7): 4291–300. PMC 109013. PMID 9632813. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109013. 
  2. ^ a b Fu TJ, Peng J, Lee G, Price DH, Flores O (Feb 2000). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". J Biol Chem 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912. 
  3. ^ a b "Entrez Gene: CCNK cyclin K". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8812. 

Further reading


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