DCUN1D1

DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Identifiers
Symbols	DCUN1D1; DCUN1L1; RP42; SCCRO; SCRO; Tes3
External IDs	OMIM: 605905 MGI: 2150386 HomoloGene: 10773 GeneCards: DCUN1D1 Gene
Gene Ontology Molecular function • protein binding Cellular component • ubiquitin ligase complex Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54165	114893
Ensembl	ENSG00000043093	ENSMUSG00000027708
UniProt	Q96GG9	Q3TMV8
RefSeq (mRNA)	NM_020640	XM_987015
RefSeq (protein)	NP_065691	XP_992109
Location (UCSC)	Chr 3: 182.66 – 182.7 Mb	Chr 3: 35.79 – 35.84 Mb
PubMed search	[1]	[2]

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.^[1][2][3]

Interactions

DCUN1D1 has been shown to interact with CAND1,^[4] RBX1,^[4] CUL1,^[4] CUL3^[4] and CUL2.^[4]

References

1. ^ Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Jun 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID 10777668. 
2. ^ Kurz T, Ozlu N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature 435 (7046): 1257–61. doi:10.1038/nature03662. PMID 15988528. 
3. ^ "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54165. 
4. ^ ^{a b c d e} Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov. 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. (United States) 283 (48): 33211–20. doi:10.1074/jbc.M804440200. ISSN 0021-9258. PMC 2586271. PMID 18826954. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2586271. 

Further reading

• Sarkaria IS, Pham D, Ghossein RA, et al. (2005). "SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma.". Ann. Thorac. Surg. 78 (5): 1734–41. doi:10.1016/j.athoracsur.2004.05.056. PMID 15511464. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Estilo CL, O-Charoenrat P, Ngai I, et al. (2004). "The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue.". Clin. Cancer Res. 9 (6): 2300–6. PMID 12796399. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Talbot SG, O-charoenrat P, Sarkaria IS, et al. (2004). "Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A.". Ann. Surg. Oncol. 11 (5): 530–4. doi:10.1245/ASO.2004.03.014. PMID 15123463. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Jacques C, Baris O, Prunier-Mirebeau D, et al. (2005). "Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.". J. Clin. Endocrinol. Metab. 90 (4): 2314–20. doi:10.1210/jc.2004-1337. PMID 15623817. 
• Sarkaria IS, Stojadinovic A, Talbot SG, et al. (2005). "Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas.". Surgery 136 (6): 1122–8. doi:10.1016/j.surg.2004.06.041. PMID 15657565. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Sarkaria I, O-charoenrat P, Talbot SG, et al. (2007). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas.". Cancer Res. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.