RBX1

Ring-box 1, also known as RBX1, is a human gene.

PBB_Summary
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summary_text = This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.cite web | title = Entrez Gene: RBX1 ring-box 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9978| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kamura T, Koepp DM, Conrad MN, "et al." |title=Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. |journal=Science |volume=284 |issue= 5414 |pages= 657–61 |year= 1999 |pmid= 10213691 |doi=
*cite journal | author=Skowyra D, Koepp DM, Kamura T, "et al." |title=Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. |journal=Science |volume=284 |issue= 5414 |pages= 662–5 |year= 1999 |pmid= 10213692 |doi=
*cite journal | author=Tan P, Fuchs SY, Chen A, "et al." |title=Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 527–33 |year= 1999 |pmid= 10230406 |doi=
*cite journal | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535–41 |year= 1999 |pmid= 10230407 |doi=
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Kamura T, Conrad MN, Yan Q, "et al." |title=The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. |journal=Genes Dev. |volume=13 |issue= 22 |pages= 2928–33 |year= 2000 |pmid= 10579999 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Périn J-P , Seddiqi N, Charbonnier F, "et al." |title=Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=45 |issue= 8 |pages= 1131–7 |year= 2000 |pmid= 10643962 |doi=
*cite journal | author=Read MA, Brownell JE, Gladysheva TB, "et al." |title=Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2326–33 |year= 2000 |pmid= 10713156 |doi=
*cite journal | author=Furukawa M, Zhang Y, McCarville J, "et al." |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=
*cite journal | author=Maeda I, Ohta T, Koizumi H, Fukuda M |title=In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3. |journal=FEBS Lett. |volume=494 |issue= 3 |pages= 181–5 |year= 2001 |pmid= 11311237 |doi=
*cite journal | author=Lyapina S, Cope G, Shevchenko A, "et al." |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382–5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780
*cite journal | author=Fukuchi M, Imamura T, Chiba T, "et al." |title=Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. |journal=Mol. Biol. Cell |volume=12 |issue= 5 |pages= 1431–43 |year= 2001 |pmid= 11359933 |doi=
*cite journal | author=Kamura T, Burian D, Yan Q, "et al." |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748–53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200
*cite journal | author=Wu K, Chen A, Tan P, Pan ZQ |title=The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 516–27 |year= 2002 |pmid= 11675391 |doi= 10.1074/jbc.M108008200
*cite journal | author=Gomes MD, Lecker SH, Jagoe RT, "et al." |title=Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14440–5 |year= 2002 |pmid= 11717410 |doi= 10.1073/pnas.251541198
*cite journal | author=Kim J, Kim JH, Lee SH, "et al." |title=The novel human DNA helicase hFBH1 is an F-box protein. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24530–7 |year= 2002 |pmid= 11956208 |doi= 10.1074/jbc.M201612200
*cite journal | author=Zheng N, Schulman BA, Song L, "et al." |title=Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. |journal=Nature |volume=416 |issue= 6882 |pages= 703–9 |year= 2002 |pmid= 11961546 |doi= 10.1038/416703a
*cite journal | author=Yoshida Y, Chiba T, Tokunaga F, "et al." |title=E3 ubiquitin ligase that recognizes sugar chains. |journal=Nature |volume=418 |issue= 6896 |pages= 438–42 |year= 2002 |pmid= 12140560 |doi= 10.1038/nature00890
*cite journal | author=Brower CS, Sato S, Tomomori-Sato C, "et al." |title=Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10353–8 |year= 2002 |pmid= 12149480 |doi= 10.1073/pnas.162424199

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