TCEB2

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B), also known as TCEB2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6923| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Garrett KP, Aso T, Bradsher JN, "et al." |title=Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 16 |pages= 7172–6 |year= 1995 |pmid= 7638163 |doi=
*cite journal | author=Duan DR, Pause A, Burgess WH, "et al." |title=Inhibition of transcription elongation by the VHL tumor suppressor protein. |journal=Science |volume=269 |issue= 5229 |pages= 1402–6 |year= 1995 |pmid= 7660122 |doi=
*cite journal | author=Aso T, Lane WS, Conaway JW, Conaway RC |title=Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. |journal=Science |volume=269 |issue= 5229 |pages= 1439–43 |year= 1995 |pmid= 7660129 |doi=
*cite journal | author=Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG |title=Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. |journal=Science |volume=269 |issue= 5229 |pages= 1444–6 |year= 1995 |pmid= 7660130 |doi=
*cite journal | author=Bradsher JN, Jackson KW, Conaway RC, Conaway JW |title=RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25587–93 |year= 1994 |pmid= 8244996 |doi=
*cite journal | author=Pause A, Lee S, Worrell RA, "et al." |title=The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2156–61 |year= 1997 |pmid= 9122164 |doi=
*cite journal | author=Li XY, Green MR |title=The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2992–6 |year= 1998 |pmid= 9765201 |doi=
*cite journal | author=Zhang JG, Farley A, Nicholson SE, "et al." |title=The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 2071–6 |year= 1999 |pmid= 10051596 |doi=
*cite journal | author=Stebbins CE, Kaelin WG, Pavletich NP |title=Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. |journal=Science |volume=284 |issue= 5413 |pages= 455–61 |year= 1999 |pmid= 10205047 |doi=
*cite journal | author=Pause A, Peterson B, Schaffar G, "et al." |title=Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9533–8 |year= 1999 |pmid= 10449727 |doi=
*cite journal | author=Iwai K, Yamanaka K, Kamura T, "et al." |title=Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 22 |pages= 12436–41 |year= 1999 |pmid= 10535940 |doi=
*cite journal | author=Ohh M, Takagi Y, Aso T, "et al." |title=Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein. |journal=J. Clin. Invest. |volume=104 |issue= 11 |pages= 1583–91 |year= 2000 |pmid= 10587522 |doi=
*cite journal | author=Aso T, Yamazaki K, Amimoto K, "et al." |title=Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6546–52 |year= 2000 |pmid= 10692460 |doi=
*cite journal | author=Kamura T, Sato S, Iwai K, "et al." |title=Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10430–5 |year= 2000 |pmid= 10973499 |doi= 10.1073/pnas.190332597
*cite journal | author=Aso T, Yamazaki K, Aigaki T, Kitajima S |title=Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 355–61 |year= 2000 |pmid= 11006129 |doi= 10.1006/bbrc.2000.3451
*cite journal | author=Kamura T, Burian D, Yan Q, "et al." |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748–53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200
*cite journal | author=Li Z, Na X, Wang D, "et al." |title=Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4656–62 |year= 2002 |pmid= 11739384 |doi= 10.1074/jbc.M108269200
*cite journal | author=Yamazaki K, Guo L, Sugahara K, "et al." |title=Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26444–51 |year= 2002 |pmid= 11994304 |doi= 10.1074/jbc.M202859200
*cite journal | author=Min JH, Yang H, Ivan M, "et al." |title=Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. |journal=Science |volume=296 |issue= 5574 |pages= 1886–9 |year= 2002 |pmid= 12004076 |doi= 10.1126/science.1073440
*cite journal | author=Hon WC, Wilson MI, Harlos K, "et al." |title=Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. |journal=Nature |volume=417 |issue= 6892 |pages= 975–8 |year= 2002 |pmid= 12050673 |doi= 10.1038/nature00767

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