PDE6D

Phosphodiesterase 6D, cGMP-specific, rod, delta
PDB rendering based on 1ksg.
Available structures PDB 1KSG, 1KSH, 1KSJ
Identifiers
Symbols	PDE6D; PDED
External IDs	OMIM: 602676 MGI: 1270843 HomoloGene: 1954 GeneCards: PDE6D Gene
EC number	3.1.4.17
Gene Ontology Molecular function • 3',5'-cyclic-nucleotide phosphodiesterase activity • GTPase inhibitor activity • protein binding Biological process • visual perception • regulation of GTP catabolic process • response to stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5147	18582
Ensembl	ENSG00000156973	ENSMUSG00000026239
UniProt	O43924	Q3TDQ8
RefSeq (mRNA)	NM_002601	XM_974388
RefSeq (protein)	NP_002592	NP_032827.1
Location (UCSC)	Chr 2: 232.6 – 232.65 Mb	Chr 1: 88.44 – 88.48 Mb
PubMed search	[1]	[2]

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.^[1][2][3]

Interactions

PDE6D has been shown to interact with ARL2,^[4][5] RAP1A,^[6][5] Rnd1,^[6][5] Retinitis pigmentosa GTPase regulator^[7] and HRAS.^[5][6]

References

1. ^ Ershova G, Derre J, Chetelin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J (Apr 1998). "cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36". Cytogenet Cell Genet 79 (1–2): 139–41. doi:10.1159/000134701. PMID 9533031. 
2. ^ Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W (Jun 1998). "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene". Genomics 49 (1): 76–82. doi:10.1006/geno.1998.5210. PMID 9570951. 
3. ^ "Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5147. 
4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
5. ^ ^{a b c d} Hanzal-Bayer, Michael; Renault Louis, Roversi Pietro, Wittinghofer Alfred, Hillig Roman C (May. 2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. (England) 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. ISSN 0261-4189. PMC 125981. PMID 11980706. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125981. 
6. ^ ^{a b c} Nancy, Vanessa; Callebaut Isabelle, El Marjou Ahmed, de Gunzburg Jean (Apr. 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. (United States) 277 (17): 15076–84. doi:10.1074/jbc.M109983200. ISSN 0021-9258. PMID 11786539. 
7. ^ Linari, M; Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb. 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1315–20. doi:10.1073/pnas.96.4.1315. ISSN 0027-8424. PMC 15460. PMID 9990021. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15460. 

Further reading

• Marzesco AM, Galli T, Louvard D, Zahraoui A (1998). "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes". J. Biol. Chem. 273 (35): 22340–5. doi:10.1074/jbc.273.35.22340. PMID 9712853. 
• Lorenz B, Migliaccio C, Lichtner P, et al. (1998). "Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse". Eur. J. Hum. Genet. 6 (3): 283–90. doi:10.1038/sj.ejhg.5200215. PMID 9781033. 
• Linari M, Ueffing M, Manson F, et al. (1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1315–20. doi:10.1073/pnas.96.4.1315. PMC 15460. PMID 9990021. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15460. 
• Mou H, Grazio HJ, Cook TA, et al. (1999). "cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits". J. Biol. Chem. 274 (26): 18813–20. doi:10.1074/jbc.274.26.18813. PMID 10373499. 
• Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Lett. 458 (1): 55–9. doi:10.1016/S0014-5793(99)01117-5. PMID 10518933. 
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539. 
• Hanzal-Bayer M, Renault L, Roversi P, et al. (2002). "The complex of Arl2-GTP and PDEδ: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125981. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Wilson SJ, Smyth EM (2006). "Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6". J. Biol. Chem. 281 (17): 11780–6. doi:10.1074/jbc.M513110200. PMID 16527812.