PDE1A

Phosphodiesterase 1A, calmodulin-dependent
Identifiers
Symbols	PDE1A; HCAM1; HSPDE1A; MGC26303
External IDs	OMIM: 171890 MGI: 1201792 HomoloGene: 21043 GeneCards: PDE1A Gene
EC number	3.1.4.17
Gene Ontology Molecular function • 3',5'-cyclic-AMP phosphodiesterase activity • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • calmodulin binding • phosphoric diester hydrolase activity • hydrolase activity • metal ion binding • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytosol • cytosol Biological process • signal transduction • activation of phospholipase C activity • blood coagulation • platelet activation • nerve growth factor receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5136	18573
Ensembl	ENSG00000115252	ENSMUSG00000059173
UniProt	P54750	Q8BRR9
RefSeq (mRNA)	NM_001003683.1	NM_001009978
RefSeq (protein)	NP_001003683.1	NP_001009978
Location (UCSC)	Chr 2: 183 – 183.39 Mb	Chr 2: 79.67 – 79.97 Mb
PubMed search	[1]	[2]

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.^[1][2][3]

References

1. ^ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689. 
2. ^ Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta 1517 (2): 278–87. PMID 11342109. 
3. ^ "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5136. 

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Snyder PB, Florio VA, Ferguson K, Loughney K (1999). "Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A).". Cell. Signal. 11 (7): 535–44. doi:10.1016/S0898-6568(99)00027-3. PMID 10405764. 
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
• Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604. 
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants.". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989. 
• Ritter M, Buechler C, Boettcher A, et al. (2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.". Genomics 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719. 
• Lefièvre L, de Lamirande E, Gagnon C (2003). "Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa.". Biol. Reprod. 67 (2): 423–30. doi:10.1095/biolreprod67.2.423. PMID 12135876. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Goraya TA, Masada N, Ciruela A, Cooper DM (2004). "Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A". J. Biol. Chem. 279 (39): 40494–504. doi:10.1074/jbc.M313441200. PMID 15272012. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Nagel DJ, Aizawa T, Jeon KI, et al. (2006). "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival". Circ. Res. 98 (6): 777–84. doi:10.1161/01.RES.0000215576.27615.fd. PMID 16514069.