PDE7A

Phosphodiesterase 7A
PDB rendering based on 1zkl.
Available structures PDB 1ZKL, 3G3N
Identifiers
Symbols	PDE7A; HCP1; PDE7
External IDs	OMIM: 171885 MGI: 1202402 HomoloGene: 1956 GeneCards: PDE7A Gene
EC number	3.1.4.17
Gene Ontology Molecular function • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • hydrolase activity • metal ion binding Cellular component • cell fraction • cytoplasm • cytosol Biological process • signal transduction • cAMP-mediated signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5150	18583
Ensembl	ENSG00000205268	ENSMUSG00000069094
UniProt	Q13946	Q3TFY5
RefSeq (mRNA)	NM_001242318.1	NM_008802
RefSeq (protein)	NP_001229247.1	NP_032828
Location (UCSC)	Chr 8: 66.63 – 66.75 Mb	Chr 3: 19.12 – 19.21 Mb
PubMed search	[1]	[2]

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.^[1][2][3]

References

1. ^ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem 268 (17): 12925–32. PMID 8389765. 
2. ^ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885. 
3. ^ "Entrez Gene: PDE7A phosphodiesterase 7A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5150. 

Further reading

• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. 
• Han P, Zhu X, Michaeli T (1997). "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.". J. Biol. Chem. 272 (26): 16152–7. doi:10.1074/jbc.272.26.16152. PMID 9195912. 
• Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044. 
• Miró X, Casacuberta JM, Gutiérrez-López MD, et al. (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1).". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353. 
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Glavas NA, Ostenson C, Schaefer JB, et al. (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. doi:10.1073/pnas.101131098. PMC 33466. PMID 11371644. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=33466. 
• Lee R, Wolda S, Moon E, et al. (2002). "PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.". Cell. Signal. 14 (3): 277–84. doi:10.1016/S0898-6568(01)00250-9. PMID 11812656. 
• Nakata A, Ogawa K, Sasaki T, et al. (2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.". Clin. Exp. Immunol. 128 (3): 460–6. doi:10.1046/j.1365-2249.2002.01856.x. PMC 1906253. PMID 12067300. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1906253. 
• Smith SJ, Brookes-Fazakerley S, Donnelly LE, et al. (2003). "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2): L279–89. doi:10.1152/ajplung.00170.2002 (inactive 2008-10-03). PMID 12388353. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Torras-Llort M, Azorín F (2003). "Functional characterization of the human phosphodiesterase 7A1 promoter.". Biochem. J. 373 (Pt 3): 835–43. doi:10.1042/BJ20021829. PMC 1223549. PMID 12737631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223549. 
• Wang H, Liu Y, Chen Y, et al. (2005). "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.". J. Biol. Chem. 280 (35): 30949–55. doi:10.1074/jbc.M504398200. PMID 15994308.