GNL3

GNL3
Guanine nucleotide binding protein-like 3 (nucleolar)
Identifiers
Symbols GNL3; C77032; E2IG3; MGC800; NS
External IDs OMIM608011 MGI1353651 HomoloGene56670 GeneCards: GNL3 Gene
RNA expression pattern
PBB GE GNL3 217850 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26354 30877
Ensembl ENSG00000163938 ENSMUSG00000042354
UniProt Q9BVP2 Q3TK27
RefSeq (mRNA) NM_014366.4 NM_153547.5
RefSeq (protein) NP_055181.3 NP_705775.2
Location (UCSC) Chr 3:
52.72 – 52.73 Mb
Chr 14:
31.83 – 31.83 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein-like 3 also known as nucleostemin is a protein that in humans is encoded by the GNL3 gene.[1][2][3] It is found within the nucleolus that binds p53.[4] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[4] It is a marker for many stem cells and cancer cells.[5]


Interactions

GNL3 has been shown to interact with Mdm2[6] and P53.[2]

References

  1. ^ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res 60 (21): 5977–83. PMID 11085516. 
  2. ^ a b Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187487. 
  3. ^ "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26354. 
  4. ^ a b Ross, Michael H.; Pawlina, Wojciech. (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. pp. 79. ISBN 0781772001. 
  5. ^ Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. http://books.google.com/books?id=dpceD8fZ1B0C&pg=PA31. Retrieved 27 September 2011. 
  6. ^ Dai, Mu-Shui; Sun Xiao-Xin, Lu Hua (Jul. 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. (United States) 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2447154. 

Further reading


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Look at other dictionaries:

  • GNL3 — Proteína 3 de unión al nucleótido guanina HUGO 29931 Símbolo GNL3 Símbolos alt. NS; C77032; E2IG3; MGC800 …   Wikipedia Español

  • Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2. [1] …   Wikipedia

  • Jean-Joseph de Verneilh-Puyraseau — Le Baron Jean Joseph de Verneilh Puyraseau (1756 1839) était un homme politique français, député en 1791 et au Corps législatif en 1810, représentant aux Cent Jours, député de 1817 à 1824 et de 1827 à 1830. Sommaire 1 Biographie 1.1 …   Wikipédia en Français

  • Verneilh Puyraseau — Jean Joseph de Verneilh Puyraseau Le Baron Jean Joseph de Verneilh Puyraseau (1756 1839) était un homme politique français, député en 1791 et au Corps législatif en 1810, représentant aux Cent Jours, député de 1817 à 1824 et de 1827 à 1830.… …   Wikipédia en Français

  • p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP …   Wikipedia

  • Mdm2 — Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) Estructura tridimensional de la proteína Mdm2. HUGO 6973 …   Wikipedia Español

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