NDRG2

NDRG family member 2
Identifiers
Symbols	NDRG2; DKFZp781G1938; FLJ25522; KIAA1248; SYLD
External IDs	OMIM: 605272 MGI: 1352498 HomoloGene: 22785 GeneCards: NDRG2 Gene
Gene Ontology Molecular function • molecular_function Cellular component • nucleus • nucleolus • cytoplasm • Golgi apparatus • centrosome • cytosol • perinuclear region of cytoplasm Biological process • negative regulation of cytokine production • signal transduction • multicellular organismal development • nervous system development • regulation of vascular endothelial growth factor production • cell differentiation • negative regulation of smooth muscle cell proliferation • negative regulation of ERK1 and ERK2 cascade • regulation of platelet-derived growth factor production Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57447	29811
Ensembl	ENSG00000165795	ENSMUSG00000004558
UniProt	Q9UN36	Q8CGR9
RefSeq (mRNA)	NM_016250.2	NM_013864
RefSeq (protein)	NP_057334.1	NP_038892
Location (UCSC)	Chr 14: 21.48 – 21.54 Mb	Chr 14: 52.52 – 52.53 Mb
PubMed search	[1]	[2]

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstrean-regulated gene 2).^[1][2]

Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[2]

References

1. ^ Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK (Aug 2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1287101. 
2. ^ ^{a b} "Entrez Gene: NDRG2 NDRG family member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57447. 

Further reading

• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.". Genomics 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569. 
• Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.". Mol. Cell. Biochem. 229 (1-2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845. 
• Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells.". Brain Res. Dev. Brain Res. 135 (1-2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Deng Y, Yao L, Chau L, et al. (2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation.". Int. J. Cancer 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671. 
• Choi SC, Kim KD, Kim JT, et al. (2003). "Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells.". FEBS Lett. 553 (3): 413–8. doi:10.1016/S0014-5793(03)01030-5. PMID 14572661. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004. 
• Mitchelmore C, Büchmann-Møller S, Rask L, et al. (2004). "NDRG2: a novel Alzheimer's disease associated protein.". Neurobiol. Dis. 16 (1): 48–58. doi:10.1016/j.nbd.2004.01.003. PMID 15207261. 
• Murray JT, Campbell DG, Morrice N, et al. (2005). "Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.". Biochem. J. 384 (Pt 3): 477–88. doi:10.1042/BJ20041057. PMC 1134133. PMID 15461589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134133. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Hu XL, Liu XP, Lin SX, et al. (2005). "NDRG2 expression and mutation in human liver and pancreatic cancers.". World J. Gastroenterol. 10 (23): 3518–21. PMID 15526377. 
• Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.". Virology 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID 15582665. 
• Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829. 
• Lusis EA, Watson MA, Chicoine MR, et al. (2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma.". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.