Defensin, alpha 1

Defensin, alpha 1
Defensin, alpha 1

PDB rendering based on 1dfn.
Symbols DEFA1; DEF1; DEFA1B; DEFA2; HNP-1; HP-1; HP1; MGC138393; MRS
External IDs OMIM125220 HomoloGene121760 GeneCards: DEFA1 Gene
RNA expression pattern
PBB GE DEFA1 205033 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1667 n/a
Ensembl ENSG00000185918 n/a
UniProt P59665 n/a
RefSeq (mRNA) NM_004084 n/a
RefSeq (protein) NP_004075 n/a
Location (UCSC) Chr 8:
6.86 – 6.86 Mb
PubMed search [1] n/a

Defensin, alpha 1 also known as human alpha defensin 1, human neutrophil peptide 1 (HNP-1) or neutrophil defensin 1 is a human protein that is encoded by the DEFA1 gene.[1][2][3] Human alpha defensin 1 belongs to the alpha defensin family of antimicrobial peptides.


Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from the defensins, alpha 2 and alpha 3 by only one amino acid.[3]


  1. ^ Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM (Mar 1997). "Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes". J Neurosci 17 (5): 1539–47. PMID 9030614. 
  2. ^ Aldred PM, Hollox EJ, Armour JA (Jul 2005). "Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3". Hum Mol Genet 14 (14): 2045–52. doi:10.1093/hmg/ddi209. PMID 15944200. 
  3. ^ a b "Entrez Gene: DEFA1 defensin, alpha 1". 

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