DEFA6

Defensin, alpha 6, Paneth cell-specific
PDB rendering based on 1zmq.
Available structures PDB 1zmq
Identifiers
Symbols	DEFA6; DEF6; HD-6
External IDs	OMIM: 600471 MGI: 99582 GeneCards: DEFA6 Gene
Gene Ontology Cellular component • extracellular region • extracellular space Biological process • killing of cells of other organism • defense response to bacterium • defense response to fungus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1671	n/a
Ensembl	ENSG00000164822	n/a
UniProt	Q01524	n/a
RefSeq (mRNA)	NM_001926	n/a
RefSeq (protein)	NP_001917	n/a
Location (UCSC)	Chr 8: 6.78 – 6.78 Mb	n/a
PubMed search	[1]	n/a

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene.^[1][2] DEFA6 is expressed in the Paneth cells of the ileum.^[3]

Function

The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 was reported to possess poor antibacterial potency.^[4]

Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.^[1]

References

1. ^ ^{a b} "Entrez Gene: DEFA6 defensin, alpha 6, Paneth cell-specific (Homo sapiens)". http://www.ncbi.nlm.nih.gov/gene?term=DEFa6. 
2. ^ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Lett. 315 (2): 187–92. doi:10.1016/0014-5793(93)81160-2. PMID 8417977. 
3. ^ Zhao C, Wang I, Lehrer RI (24 Nov 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Lett 396 (2-3): 319–22. doi:10.1016/0014-5793(96)01123-4. PMID 8915011. 
4. ^ Ericksen B, Wu Z, Lu W, Lehrer RI. (2005). "Antibacterial activity and specificity of the six human alpha defensins.". Antimicrob Agents Chemother. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=538877. 

Further reading

• Szyk A, Wu Z, Tucker K, et al. (2006). "Crystal structures of human alpha-defensins HNP4, HD5, and HD6.". Protein Sci. 15 (12): 2749–60. doi:10.1110/ps.062336606. PMC 2242434. PMID 17088326. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2242434. 
• Wu Z, Ericksen B, Tucker K, et al. (2004). "Synthesis and characterization of human alpha-defensins 4-6.". J Pept Res. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502. 
• Mallow EB, Harris A, Salzman N, et al. (1996). "Human enteric defensins. Gene structure and developmental expression.". J. Biol. Chem. 271 (8): 4038–45. doi:10.1074/jbc.271.8.4038. PMID 8626737. 
• Bevins CL, Jones DE, Dutra A, et al. (1996). "Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships.". Genomics 31 (1): 95–106. doi:10.1006/geno.1996.0014. PMID 8808285. 
• Eisenhauer PB, Harwig SS, Lehrer RI (September 1992). "Cryptdins: antimicrobial defensins of the murine small intestine". Infect. Immun. 60 (9): 3556–65. PMC 257361. PMID 1500163. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=257361. 
• Huttner KM, Selsted ME, Ouellette AJ (February 1994). "Structure and diversity of the murine cryptdin gene family". Genomics 19 (3): 448–53. doi:10.1006/geno.1994.1093. PMID 8188287.