N-acetylglucosamine kinase

N-acetylglucosamine kinase
N-acetylglucosamine kinase
Identifiers
EC number 2.7.1.59
CAS number 9027-48-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-glucosamine \rightleftharpoons ADP + N-acetyl-D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-glucosamine, whereas its two products are ADP and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, 2-acetylamino-2-deoxy-D-glucose kinase, and acetylaminodeoxyglucokinase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2CH5, 2CH6, and 2HOE.

References

  • Asensio C and Ruiz-Amil M (1966). "N-Acetyl-D-glucosamine kinase. II. Escherichia coli". Methods Enzymol. 9: 421–425. doi:10.1016/0076-6879(66)09086-4. 
  • Barkulis SS (1966). "N-Acetyl-D-glucosamine kinase. I. Streptococcus pyogenes". Methods Enzymol. 9: 415–420. doi:10.1016/0076-6879(66)09085-2. 
  • Datta A (1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase". Biochim. Biophys. Acta. 220 (1): 51–60. PMID 4319609. 
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