Choline-phosphate cytidylyltransferase

choline-phosphate cytidylyltransferase
Identifiers
EC number	2.7.7.15
CAS number	9026-34-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction

CTP + choline phosphate $\rightleftharpoons$ diphosphate + CDP-choline

Thus, the two substrates of this enzyme are CTP and choline phosphate, whereas its two products are diphosphate and CDP-choline.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1PEH and 1PEI.

References

• BORKENHAGEN LF, KENNEDY EP (1957). "The enzymatic synthesis of cytidine diphosphate choline". J. Biol. Chem. 227 (2): 951–62. PMID 13463016. 
• KENNEDY EP, WEISS SB (1956). "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222 (1): 193–214. PMID 13366993. 
• Williams-Ashman HG and Banks J (1956). "Participation of cytidine coenzymes in the metabolism of choline by seminal vesicles". J. Biol. Chem. 223 (1): 509–521. PMID 13376620.