PCYT1A

Phosphate cytidylyltransferase 1, choline, alpha
PDB rendering based on 1peh.
Available structures PDB 1peh
Identifiers
Symbols	PCYT1A; CCTA; CT; CTA; CTPCT; PCYT1
External IDs	OMIM: 123695 MGI: 88557 HomoloGene: 3680 GeneCards: PCYT1A Gene
EC number	2.7.7.15
Gene Ontology Molecular function • choline-phosphate cytidylyltransferase activity • lipid binding • transferase activity • nucleotidyltransferase activity Cellular component • soluble fraction • cytoplasm • endoplasmic reticulum membrane • cytosol • membrane • glycogen granule Biological process • CDP-choline pathway • phospholipid biosynthetic process • biosynthetic process • response to abiotic stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5130	13026
Ensembl	ENSG00000161217	ENSMUSG00000005615
UniProt	P49585	P49586
RefSeq (mRNA)	NM_005017	NM_009981
RefSeq (protein)	NP_005008	NP_034111
Location (UCSC)	Chr 3: 195.94 – 196.01 Mb	Chr 16: 32.43 – 32.48 Mb
PubMed search	[1]	[2]

Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene.^[1][2]

References

1. ^ Kalmar GB, Kay RJ, LaChance AC, Cornell RB (Nov 1994). "Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase". Biochim Biophys Acta 1219 (2): 328–34. PMID 7918629. 
2. ^ "Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5130. 

Further reading

• Hunt AN, Normand CS, Postle AD (1990). "CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin.". Biochim. Biophys. Acta 1043 (1): 19–26. PMID 2155660. 
• Vance JE, Vance DE (1988). "Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion?". J. Biol. Chem. 263 (12): 5898–909. PMID 2833521. 
• Weinhold PA, Feldman DA (1995). "Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein.". Arch. Biochem. Biophys. 318 (1): 147–56. doi:10.1006/abbi.1995.1215. PMID 7726555. 
• Johnson JE, Cornell RB (1994). "Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase.". Biochemistry 33 (14): 4327–35. doi:10.1021/bi00180a029. PMID 8155650. 
• Dunne SJ, Cornell RB, Johnson JE, et al. (1996). "Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase.". Biochemistry 35 (37): 11975–84. doi:10.1021/bi960821. PMID 8810902. 
• Arnold RS, DePaoli-Roach AA, Cornell RB (1997). "Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes.". Biochemistry 36 (20): 6149–56. doi:10.1021/bi970023z. PMID 9166786. 
• Yang J, Wang J, Tseu I, et al. (1997). "Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions.". Biochem. J.. 325 ( Pt 1): 29–38. PMC 1218525. PMID 9224626. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218525. 
• Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant.". J. Biol. Chem. 274 (38): 26992–7001. doi:10.1074/jbc.274.38.26992. PMID 10480912. 
• Lagace TA, Miller JR, Ridgway ND (2002). "Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.". Mol. Cell. Biol. 22 (13): 4851–62. doi:10.1128/MCB.22.13.4851-4862.2002. PMC 133913. PMID 12052891. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133913. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Guenther MG, Yu J, Kao GD, et al. (2003). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187500. 
• Xie M, Smith JL, Ding Z, et al. (2004). "Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase.". J. Biol. Chem. 279 (27): 28817–25. doi:10.1074/jbc.M403311200. PMID 15069071. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Enaw JO, Zhu H, Yang W, et al. (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.". BMC medicine 4: 36. doi:10.1186/1741-7015-4-36. PMC 1770928. PMID 17184542. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1770928.