CHKA

CHKA

Choline kinase alpha, also known as CHKA, is a human gene.cite web | title = Entrez Gene: CHKA choline kinase alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1119| accessdate = ]

PBB_Summary
section_title =
summary_text = The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: CHKA choline kinase alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1119| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aoyama C, Liao H, Ishidate K |title=Structure and function of choline kinase isoforms in mammalian cells. |journal=Prog. Lipid Res. |volume=43 |issue= 3 |pages= 266–81 |year= 2004 |pmid= 15003397 |doi= 10.1016/j.plipres.2003.12.001
*cite journal | author=Spanner S, Ansell GB |title=Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain. |journal=Biochem. J. |volume=178 |issue= 3 |pages= 753–60 |year= 1979 |pmid= 36885 |doi=
*cite journal | author=Spanner S, Ansell GB |title=Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain. |journal=Adv. Exp. Med. Biol. |volume=101 |issue= |pages= 237–45 |year= 1978 |pmid= 208357 |doi=
*cite journal | author=Hosaka K, Tanaka S, Nikawa J, Yamashita S |title=Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. |journal=FEBS Lett. |volume=304 |issue= 2-3 |pages= 229–32 |year= 1992 |pmid= 1618328 |doi=
*cite journal | author=Kaplan O, Cohen JS |title=Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways. |journal=Immunomethods |volume=4 |issue= 2 |pages= 139–47 |year= 1994 |pmid= 8069533 |doi=
*cite journal | author=Price DJ, Rivnay B, Fu Y, "et al." |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5915–20 |year= 1997 |pmid= 9038210 |doi=
*cite journal | author=Ross BM, Moszczynska A, Blusztajn JK, "et al." |title=Phospholipid biosynthetic enzymes in human brain. |journal=Lipids |volume=32 |issue= 4 |pages= 351–8 |year= 1997 |pmid= 9113621 |doi=
*cite journal | author=Nakagami K, Uchida T, Ohwada S, "et al." |title=Increased choline kinase activity and elevated phosphocholine levels in human colon cancer. |journal=Jpn. J. Cancer Res. |volume=90 |issue= 4 |pages= 419–24 |year= 1999 |pmid= 10363580 |doi=
*cite journal | author=Ramírez de Molina A, Penalva V, Lucas L, Lacal JC |title=Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. |journal=Oncogene |volume=21 |issue= 6 |pages= 937–46 |year= 2002 |pmid= 11840339 |doi= 10.1038/sj.onc.1205144
*cite journal | author=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 167–71 |year= 2002 |pmid= 12062430 |doi=
*cite journal | author=Ramírez de Molina A, Gutiérrez R, Ramos MA, "et al." |title=Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. |journal=Oncogene |volume=21 |issue= 27 |pages= 4317–22 |year= 2002 |pmid= 12082619 |doi= 10.1038/sj.onc.1205556
*cite journal | author=Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, "et al." |title=Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 580–3 |year= 2002 |pmid= 12176020 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gallego-Ortega D, Ramirez De Molina A, Gutierrez R, "et al." |title=Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer. |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 335–40 |year= 2006 |pmid= 16820874 |doi=
*cite journal | author=Enaw JO, Zhu H, Yang W, "et al." |title=CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. |journal=BMC medicine |volume=4 |issue= |pages= 36 |year= 2007 |pmid= 17184542 |doi= 10.1186/1741-7015-4-36

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