- Mycocerosate synthase
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mycocerosate synthase Identifiers EC number 2.3.1.111 CAS number 95229-19-9 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a mycocerosate synthase (EC 2.3.1.111) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+
multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+
The 4 substrates of this enzyme are acyl-CoA, methylmalonyl-CoA, NADPH, and H+, whereas its 4 products are multi-methyl-branched acyl-CoA, CoA, CO2, and NADP+.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). This enzyme is also called mycocerosic acid synthase.
References
- Rainwater DL, Kolattukudy PE (1985). "Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA". J. Biol. Chem. 260 (1): 616–23. PMID 3880746.
This transferase article is a stub. You can help Wikipedia by expanding it. - acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+
