Histidine-tRNA ligase

In enzymology, a histidine-tRNA ligase (EC number|6.1.1.21) is an enzyme that catalyzes the chemical reaction

:ATP + L-histidine + tRNAHis $ightleftharpoons$ AMP + diphosphate + L-histidyl-tRNAHis

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase. This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1ADJ, PDB link|1ADY, PDB link|1H4V, PDB link|1HTT, PDB link|1KMM, PDB link|1KMN, PDB link|1QE0, PDB link|1WU7, and PDB link|1X59.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9068-78-4."

Gene Ontology (GO) codes