Cortisol sulfotransferase

Cortisol sulfotransferase
cortisol sulfotransferase
Identifiers
EC number 2.8.2.18
CAS number 71427-08-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cortisol sulfotransferase (EC 2.8.2.18) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + cortisol \rightleftharpoons adenosine 3',5'-bisphosphate + cortisol 21-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and cortisol, whereas its two products are adenosine 3',5'-bisphosphate and cortisol 21-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase. Other names in common use include glucocorticosteroid sulfotransferase, and glucocorticoid sulfotransferase.

References

  • Singer SS, Brill B (1982). "Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol". Biochim. Biophys. Acta. 712 (3): 590–6. PMID 6957246. 
  • Singer SS, Giera D, Johnson J, Sylvester S (1976). "Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations". Endocrinology. 98 (4): 963–74. doi:10.1210/endo-98-4-963. PMID 1278101. 
This transferase article is a stub. You can help Wikipedia by expanding it.