N-acetylornithine carbamoyltransferase

N-acetylornithine carbamoyltransferase
Identifiers
EC number	2.1.3.9
CAS number	890853-54-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a N-acetylornithine carbamoyltransferase (EC 2.1.3.9) is an enzyme that catalyzes the chemical reaction

carbamoyl phosphate + N₂-acetyl-L-ornithine $\rightleftharpoons$ phosphate + N-acetyl-L-citrulline

Thus, the two substrates of this enzyme are carbamoyl phosphate and N2-acetyl-L-ornithine, whereas its two products are phosphate and N-acetyl-L-citrulline.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase. Other names in common use include acetylornithine transcarbamylase, N-acetylornithine transcarbamylase, AOTC, and carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2G65, 2G68, 2G6A, and 2G6C.

References

• Tuchman M; Morizono, H; Yu, X; Roth, L; Caldovic, L; Allewell, NM; Malamy, MH; Tuchman, M (2005). "Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria". J. Biol. Chem. 280 (15): 14366–9. doi:10.1074/jbc.C500005200. PMID 15731101. 

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase - 3-methyl-2-oxobutanoate hydroxymethyltransferase
Formyltransferase	Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase
Other	Glutamate formimidoyltransferase - Aminomethyltransferase

2.1.3: Carboxy- and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase
Carbamoyl	Aspartate carbamoyltransferase - Ornithine carbamoyltransferase - Oxamate carbamoyltransferase - Putrescine carbamoyltransferase - 3-hydroxymethylcephem carbamoyltransferase - Lysine carbamoyltransferase - N-acetylornithine carbamoyltransferase

2.1.4: Amidino

Arginine:glycine amidinotransferase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6