3-methyl-2-oxobutanoate hydroxymethyltransferase

In enzymology, a 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC number|2.1.2.11) is an enzyme that catalyzes the chemical reaction

:5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H₂O $ightleftharpoons$ tetrahydrofolate + 2-dehydropantoate

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, 3-methyl-2-oxobutanoate, and H₂O, whereas its two products are tetrahydrofolate and 2-dehydropantoate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase. Other names in common use include alpha-ketoisovalerate hydroxymethyltransferase, dehydropantoate hydroxymethyltransferase, ketopantoate hydroxymethyltransferase, oxopantoate hydroxymethyltransferase, 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate, and hydroxymethyltransferase. This enzyme participates in pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1M3U, PDB link|1O66, PDB link|1O68, and PDB link|1OY0.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|56093-17-5."

Gene Ontology (GO) codes