Methionine gamma-lyase

methionine gamma-lyase
Identifiers
EC number	4.4.1.11
CAS number	42616-25-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a methionine gamma-lyase (EC 4.4.1.11) is an enzyme that catalyzes the chemical reaction

L-methionine + H₂O $\rightleftharpoons$ methanethiol + NH₃ + 2-oxobutanoate

Thus, the two substrates of this enzyme are L-methionine and H₂O, whereas its 3 products are methanethiol, NH₃, and 2-oxobutanoate.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-methionine methanethiol-lyase (deaminating 2-oxobutanoate-forming). Other names in common use include L-methioninase, methionine lyase, methioninase, methionine dethiomethylase, L-methionine gamma-lyase, and L-methionine methanethiol-lyase (deaminating). This enzyme participates in selenoamino acid metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1E5E, 1E5F, 1GC0, 1GC2, 1PFF, 1PG8, 1UKJ, and 1Y4I.

References

• Kreis W, Hession C (1973). "Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes". Cancer. Res. 33 (8): 1862–5. PMID 4720797. 

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