DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Rendering based on PDB 2QFB.
Symbols DDX58; DKFZp434J1111; DKFZp686N19181; FLJ13599; RIG-I
External IDs OMIM609631 MGI2442858 HomoloGene32215 GeneCards: DDX58 Gene
EC number
RNA expression pattern
PBB GE DDX58 218943 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23586 230073
Ensembl ENSG00000107201 ENSMUSG00000040296
UniProt O95786 Q05CC6
RefSeq (mRNA) NM_014314 NM_172689.3
RefSeq (protein) NP_055129 NP_766277.3
Location (UCSC) Chr 9:
32.46 – 32.53 Mb
Chr 4:
40.15 – 40.19 Mb
PubMed search [1] [2]

Probable ATP-dependent RNA helicase DDX58 is an enzyme that in humans is encoded by the DDX58 gene. It codes for a protein called retinoic acid-inducible gene 1 protein (or RIG-I), also known as DEAD-box protein 58 (DDX58), which is a cell receptor found in the cytoplasm of cells. RIG-I is part of the RIG-I-like receptor (RLR) family, which also includes MDA5 and LGP2, and functions as a pattern recognition receptor that is a sensor for viruses. DDX58 and MDA5 are involved in activating MAVS and triggering an antiviral response. [1]


DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.[2]


  1. ^ Hou, F; Sun, L, Zheng, H, Skaug, B, Jiang, QX, Chen, ZJ (2011 Aug 5). "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.". Cell 146 (3): 448–61. PMID 21782231. 
  2. ^ "Entrez Gene: DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23586. 

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