IFIH1

Interferon induced with helicase C domain 1, also known as IFIH1, is a human gene.cite web | title = Entrez Gene: IFIH1 interferon induced with helicase C domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64135| accessdate = ]

PBB_Summary
section_title =
summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.cite web | title = Entrez Gene: IFIH1 interferon induced with helicase C domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64135| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kang DC, Gopalkrishnan RV, Wu Q, "et al." |title=mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 637–42 |year= 2002 |pmid= 11805321 |doi= 10.1073/pnas.022637199
*cite journal | author=Kovacsovics M, Martinon F, Micheau O, "et al." |title=Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. |journal=Curr. Biol. |volume=12 |issue= 10 |pages= 838–43 |year= 2002 |pmid= 12015121 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cocude C, Truong MJ, Billaut-Mulot O, "et al." |title=A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication. |journal=J. Gen. Virol. |volume=84 |issue= Pt 12 |pages= 3215–25 |year= 2004 |pmid= 14645903 |doi=
*cite journal | author=Kang DC, Gopalkrishnan RV, Lin L, "et al." |title=Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. |journal=Oncogene |volume=23 |issue= 9 |pages= 1789–800 |year= 2004 |pmid= 14676839 |doi= 10.1038/sj.onc.1207300
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andrejeva J, Childs KS, Young DF, "et al." |title=The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 49 |pages= 17264–9 |year= 2005 |pmid= 15563593 |doi= 10.1073/pnas.0407639101
*cite journal | author=Yoneyama M, Kikuchi M, Matsumoto K, "et al." |title=Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. |journal=J. Immunol. |volume=175 |issue= 5 |pages= 2851–8 |year= 2005 |pmid= 16116171 |doi=
*cite journal | author=Kawai T, Takahashi K, Sato S, "et al." |title=IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. |journal=Nat. Immunol. |volume=6 |issue= 10 |pages= 981–8 |year= 2005 |pmid= 16127453 |doi= 10.1038/ni1243
*cite journal | author=Meylan E, Curran J, Hofmann K, "et al." |title=Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. |journal=Nature |volume=437 |issue= 7062 |pages= 1167–72 |year= 2005 |pmid= 16177806 |doi= 10.1038/nature04193
*cite journal | author=Lin L, Su Z, Lebedeva IV, "et al." |title=Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis. |journal=Cell Death Differ. |volume=13 |issue= 11 |pages= 1982–93 |year= 2006 |pmid= 16575407 |doi= 10.1038/sj.cdd.4401899
*cite journal | author=Smyth DJ, Cooper JD, Bailey R, "et al." |title=A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. |journal=Nat. Genet. |volume=38 |issue= 6 |pages= 617–9 |year= 2006 |pmid= 16699517 |doi= 10.1038/ng1800
*cite journal | author=Berghäll H, Sirén J, Sarkar D, "et al." |title=The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines. |journal=Microbes Infect. |volume=8 |issue= 8 |pages= 2138–44 |year= 2007 |pmid= 16782388 |doi= 10.1016/j.micinf.2006.04.005
*cite journal | author=Sirén J, Imaizumi T, Sarkar D, "et al." |title=Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. |journal=Microbes Infect. |volume=8 |issue= 8 |pages= 2013–20 |year= 2007 |pmid= 16797201 |doi= 10.1016/j.micinf.2006.02.028
*cite journal | author=Barral PM, Morrison JM, Drahos J, "et al." |title=MDA-5 is cleaved in poliovirus-infected cells. |journal=J. Virol. |volume=81 |issue= 8 |pages= 3677–84 |year= 2007 |pmid= 17267501 |doi= 10.1128/JVI.01360-06
*cite journal | author=Marinou I, Montgomery DS, Dickson MC, "et al." |title=The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. |journal=Arthritis Res. Ther. |volume=9 |issue= 2 |pages= R40 |year= 2007 |pmid= 17442111 |doi= 10.1186/ar2179
*cite journal | author=Sutherland A, Davies J, Owen CJ, "et al." |title=Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility. |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 8 |pages= 3338–41 |year= 2007 |pmid= 17535987 |doi= 10.1210/jc.2007-0173
*cite journal | author=Matsukura S, Kokubu F, Kurokawa M, "et al." |title=Role of RIG-I, MDA-5, and PKR on the expression of inflammatory chemokines induced by synthetic dsRNA in airway epithelial cells. |journal=Int. Arch. Allergy Immunol. |volume=143 Suppl 1 |issue= |pages= 80–3 |year= 2007 |pmid= 17541283 |doi= 10.1159/000101411

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