VISA (gene)

Virus-induced signaling adapter, also known as VISA, is a human gene.cite web | title = Entrez Gene: VISA virus-induced signaling adapter| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57506| accessdate = ]

PBB_Summary
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summary_text = Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005). [supplied by OMIM] cite web | title = Entrez Gene: VISA virus-induced signaling adapter| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57506| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Nagase T, Ishikawa K, Kikuno R, "et al." |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Seth RB, Sun L, Ea CK, Chen ZJ |title=Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. |journal=Cell |volume=122 |issue= 5 |pages= 669–82 |year= 2005 |pmid= 16125763 |doi= 10.1016/j.cell.2005.08.012
*cite journal | author=Kawai T, Takahashi K, Sato S, "et al." |title=IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. |journal=Nat. Immunol. |volume=6 |issue= 10 |pages= 981–8 |year= 2005 |pmid= 16127453 |doi= 10.1038/ni1243
*cite journal | author=Xu LG, Wang YY, Han KJ, "et al." |title=VISA is an adapter protein required for virus-triggered IFN-beta signaling. |journal=Mol. Cell |volume=19 |issue= 6 |pages= 727–40 |year= 2005 |pmid= 16153868 |doi= 10.1016/j.molcel.2005.08.014
*cite journal | author=Meylan E, Curran J, Hofmann K, "et al." |title=Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. |journal=Nature |volume=437 |issue= 7062 |pages= 1167–72 |year= 2005 |pmid= 16177806 |doi= 10.1038/nature04193
*cite journal | author=Li XD, Sun L, Seth RB, "et al." |title=Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 49 |pages= 17717–22 |year= 2006 |pmid= 16301520 |doi= 10.1073/pnas.0508531102
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Loo YM, Owen DM, Li K, "et al." |title=Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 15 |pages= 6001–6 |year= 2006 |pmid= 16585524 |doi= 10.1073/pnas.0601523103
*cite journal | author=Cheng G, Zhong J, Chisari FV |title=Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 22 |pages= 8499–504 |year= 2006 |pmid= 16707574 |doi= 10.1073/pnas.0602957103
*cite journal | author=Lin R, Lacoste J, Nakhaei P, "et al." |title=Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. |journal=J. Virol. |volume=80 |issue= 12 |pages= 6072–83 |year= 2006 |pmid= 16731946 |doi= 10.1128/JVI.02495-05
*cite journal | author=Saha SK, Pietras EM, He JQ, "et al." |title=Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. |journal=EMBO J. |volume=25 |issue= 14 |pages= 3257–63 |year= 2006 |pmid= 16858409 |doi= 10.1038/sj.emboj.7601220
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Opitz B, Vinzing M, van Laak V, "et al." |title=Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 36173–9 |year= 2007 |pmid= 16984921 |doi= 10.1074/jbc.M604638200
*cite journal | author=Chen Z, Benureau Y, Rijnbrand R, "et al." |title=GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. |journal=J. Virol. |volume=81 |issue= 2 |pages= 964–76 |year= 2007 |pmid= 17093192 |doi= 10.1128/JVI.02076-06
*cite journal | author=Hirata Y, Broquet AH, Menchén L, Kagnoff MF |title=Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells. |journal=J. Immunol. |volume=179 |issue= 8 |pages= 5425–32 |year= 2007 |pmid= 17911629 |doi=

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