PAWR

PAWR
PRKC, apoptosis, WT1, regulator
Identifiers
Symbols PAWR; PAR4; Par-4
External IDs OMIM601936 MGI2149961 HomoloGene1940 GeneCards: PAWR Gene
RNA expression pattern
PBB GE PAWR 204004 at tn.png
PBB GE PAWR 204005 s at tn.png
PBB GE PAWR 214237 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5074 114774
Ensembl ENSG00000177425 ENSMUSG00000035873
UniProt Q96IZ0 Q3UWE8
RefSeq (mRNA) NM_002583.2 NM_054056.2
RefSeq (protein) NP_002574.2 NP_473397.1
Location (UCSC) Chr 12:
79.99 – 80.08 Mb
Chr 10:
107.77 – 107.85 Mb
PubMed search [1] [2]

PRKC, apoptosis, WT1, regulator, also known as PAWR or Prostate apoptosis response-4 (Par-4), is a human gene coding for a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal cells.

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.[1] The active domain of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance.[2]

Interactions

PAWR has been shown to interact with WT1,[3] THAP1,[4] SLC5A1,[5] DAPK3,[6] Apoptosis antagonizing transcription factor[7] and Protein kinase Mζ.[8]

References

  1. ^ "Entrez Gene: PAWR PRKC, apoptosis, WT1, regulator". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5074. 
  2. ^ Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, Bondada S, Spear B, Rangnekar VM (2007). "Cancer resistance in transgenic mice expressing the SAC module of Par-4". Cancer Res. 67 (19): 9276–85. doi:10.1158/0008-5472.CAN-07-2124. PMID 17909035. 
  3. ^ Johnstone, R W; See R H, Sells S F, Wang J, Muthukkumar S, Englert C, Haber D A, Licht J D, Sugrue S P, Roberts T, Rangnekar V M, Shi Y (Dec. 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6945–56. ISSN 0270-7306. PMC 231698. PMID 8943350. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231698. 
  4. ^ Roussigne, Myriam; Cayrol Corinne, Clouaire Thomas, Amalric François, Girard Jean-Philippe (Apr. 2003). "THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies". Oncogene (England) 22 (16): 2432–42. doi:10.1038/sj.onc.1206271. ISSN 0950-9232. PMID 12717420. 
  5. ^ Xie, Jun; Guo Qing (Jul. 2004). "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane". J. Biol. Chem. (United States) 279 (27): 28266–75. doi:10.1074/jbc.M401495200. ISSN 0021-9258. PMID 15090548. 
  6. ^ Kawai, Taro; Akira Shizuo, Reed John C (Sep. 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Mol. Cell. Biol. (United States) 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. ISSN 0270-7306. PMC 180930. PMID 12917339. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=180930. 
  7. ^ Guo, Qing; Xie Jun (Feb. 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". J. Biol. Chem. (United States) 279 (6): 4596–603. doi:10.1074/jbc.M309811200. ISSN 0021-9258. PMID 14627703. 
  8. ^ Díaz-Meco, M T; Municio M M, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J (Sep. 1996). "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C". Cell (UNITED STATES) 86 (5): 777–86. doi:10.1016/S0092-8674(00)80152-X. ISSN 0092-8674. PMID 8797824. 

Further reading




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  • Portuguese — /pawr cheuh geez , gees , pohr ; pawr cheuh geez , gees , pohr /, adj., n., pl. Portuguese. adj. 1. of, pertaining to, or characteristic of Portugal, its inhabitants, or their language. n. 2. a native or inhabitant of Portugal. 3. a Romance… …   Universalium

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  • Portofino — /pawr teuh fee noh, pohr /; It. /pawr taw fee naw/, n. a village in NW Italy, SE of Genoa: tourist resort. 923 …   Useful english dictionary

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