DOK1

Docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Identifiers
Symbols	DOK1; MGC117395; MGC138860; P62DOK
External IDs	OMIM: 602919 MGI: 893587 HomoloGene: 1057 GeneCards: DOK1 Gene
Gene Ontology Molecular function • insulin receptor binding Cellular component • cytoplasm • cytosol • cytosol • perinuclear region of cytoplasm Biological process • signal transduction • cell surface receptor linked signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1796	13448
Ensembl	ENSG00000115325	ENSMUSG00000068335
UniProt	Q99704	Q3UWF9
RefSeq (mRNA)	NM_001197260.1	NM_010070.4
RefSeq (protein)	NP_001184189.1	NP_034200.4
Location (UCSC)	Chr 2: 74.78 – 74.78 Mb	Chr 6: 82.98 – 82.98 Mb
PubMed search	[1]	[2]

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.^[1][2][3]

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.^[4]

Interactions

DOK1 has been shown to interact with RET proto-oncogene,^[5] SH2D1A,^[6] LYN,^[7][8] RAS p21 protein activator 1,^[9][10][11] INPP5D,^[9][7] CD117,^[8] SHC1,^[9] Abl gene^[7][10] and TEC.^[7][8]

References

1. ^ Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B (Feb 1997). "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells". Cell 88 (2): 197–204. doi:10.1016/S0092-8674(00)81840-1. PMID 9008160. 
2. ^ Nelms K, Snow AJ, Noben-Trauth K (Dec 1998). "Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia". Genomics 53 (2): 243–5. doi:10.1006/geno.1998.5514. PMID 9790776. 
3. ^ Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (Feb 2005). "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells". J Biol Chem 280 (5): 3151–8. doi:10.1074/jbc.M411035200. PMID 15546884. 
4. ^ "Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1796. 
5. ^ Murakami, Hideki; Yamamura Yumiko, Shimono Yohei, Kawai Kumi, Kurokawa Kei, Takahashi Masahide (Sep. 2002). "Role of Dok1 in cell signaling mediated by RET tyrosine kinase". J. Biol. Chem. (United States) 277 (36): 32781–90. doi:10.1074/jbc.M202336200. ISSN 0021-9258. PMID 12087092. 
6. ^ Sylla, B S; Murphy K, Cahir-McFarland E, Lane W S, Mosialos G, Kieff E (Jun. 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (13): 7470–5. doi:10.1073/pnas.130193097. ISSN 0027-8424. PMC 16569. PMID 10852966. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16569. 
7. ^ ^{a b c d} van Dijk, T B; van Den Akker E, Amelsvoort M P, Mano H, Löwenberg B, von Lindern M (Nov. 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood (UNITED STATES) 96 (10): 3406–13. ISSN 0006-4971. PMID 11071635. 
8. ^ ^{a b c} Liang, Xiquan; Wisniewski David, Strife Annabel, Shivakrupa , Clarkson Bayard, Resh Marilyn D (Apr. 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. (United States) 277 (16): 13732–8. doi:10.1074/jbc.M200277200. ISSN 0021-9258. PMID 11825908. 
9. ^ ^{a b c} Dunant, N M; Wisniewski D, Strife A, Clarkson B, Resh M D (May. 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. (ENGLAND) 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. ISSN 0898-6568. PMID 10822173. 
10. ^ ^{a b} Yamanashi, Y; Baltimore D (Jan. 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell (UNITED STATES) 88 (2): 205–11. doi:10.1016/S0092-8674(00)81841-3. ISSN 0092-8674. PMID 9008161. 
11. ^ Némorin, J G; Duplay P (May. 2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. (UNITED STATES) 275 (19): 14590–7. doi:10.1074/jbc.275.19.14590. ISSN 0021-9258. PMID 10799545. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Wisniewski D, Strife A, Wojciechowicz D et al. (1994). "A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations". Leukemia 8 (4): 688–93. PMID 8152267. 
• Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yamanashi Y, Baltimore D (1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok". Cell 88 (2): 205–11. doi:10.1016/S0092-8674(00)81841-3. PMID 9008161. 
• Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Vuica M, Desiderio S, Schneck JP (1997). "Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62". J. Exp. Med. 186 (2): 259–67. doi:10.1084/jem.186.2.259. PMC 2198989. PMID 9221755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2198989. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Chen M, She H, Davis EM et al. (1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". J. Biol. Chem. 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. PMID 9737977. 
• Noguchi T, Matozaki T, Inagaki K et al. (1999). "Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration". EMBO J. 18 (7): 1748–60. doi:10.1093/emboj/18.7.1748. PMC 1171261. PMID 10202139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171261. 
• Cong F, Yuan B, Goff SP (2000). "Characterization of a novel member of the DOK family that binds and modulates Abl signaling". Mol. Cell. Biol. 19 (12): 8314–25. PMC 84915. PMID 10567556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84915. 
• Berg KL, Siminovitch KA, Stanley ER (2000). "SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages". J. Biol. Chem. 274 (50): 35855–65. doi:10.1074/jbc.274.50.35855. PMID 10585470. 
• Becker E, Huynh-Do U, Holland S et al. (2000). "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation". Mol. Cell. Biol. 20 (5): 1537–45. doi:10.1128/MCB.20.5.1537-1545.2000. PMC 85333. PMID 10669731. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85333. 
• Némorin JG, Duplay P (2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. doi:10.1074/jbc.275.19.14590. PMID 10799545. 
• Dunant NM, Wisniewski D, Strife A et al. (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173. 
• Yoshida K, Yamashita Y, Miyazato A et al. (2000). "Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1". J. Biol. Chem. 275 (32): 24945–52. doi:10.1074/jbc.M909012199. PMID 10823839. 
• Sylla BS, Murphy K, Cahir-McFarland E et al. (2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16569. 
• Hubert P, Ferreira V, Debre P, Bismuth G (2000). "Molecular cloning of a truncated p62Dok1 isoform, p22Dok(del)". Eur. J. Immunogenet. 27 (3): 145–8. doi:10.1046/j.1365-2370.2000.00203.x. PMID 10940083. 
• Songyang Z, Yamanashi Y, Liu D, Baltimore D (2001). "Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling". J. Biol. Chem. 276 (4): 2459–65. doi:10.1074/jbc.M005504200. PMID 11042170. 

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