CYR61

Cysteine-rich, angiogenic inducer, 61
Identifiers
Symbols	CYR61; CCN1; GIG1; IGFBP10
External IDs	OMIM: 602369 MGI: 88613 HomoloGene: 1194 GeneCards: CYR61 Gene
Gene Ontology Molecular function • integrin binding • insulin-like growth factor binding • heparin binding • extracellular matrix binding Cellular component • extracellular region Biological process • regulation of cell growth • positive regulation of protein phosphorylation • intussusceptive angiogenesis • atrioventricular valve morphogenesis • apoptosis involved in heart morphogenesis • ventricular septum development • chemotaxis • cell proliferation • anatomical structure morphogenesis • positive regulation of phospholipase activity • positive regulation of cell-substrate adhesion • extracellular matrix organization • positive regulation of cell migration • positive regulation of BMP signaling pathway • positive regulation of osteoblast proliferation • positive regulation of apoptosis • negative regulation of apoptosis • positive regulation of caspase activity • wound healing, spreading of cells • positive regulation of osteoblast differentiation • positive regulation of protein kinase activity • positive regulation of transcription from RNA polymerase II promoter • response to protein stimulus • atrial septum morphogenesis • chondroblast differentiation • chorio-allantoic fusion • labyrinthine layer blood vessel development • positive regulation of cartilage development • regulation of ERK1 and ERK2 cascade • positive regulation of ceramide biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3491	16007
Ensembl	ENSG00000142871	ENSMUSG00000028195
UniProt	O00622	Q3TX21
RefSeq (mRNA)	NM_001554.4	NM_010516.2
RefSeq (protein)	NP_001545.2	NP_034646.1
Location (UCSC)	Chr 1: 86.05 – 86.05 Mb	Chr 3: 145.31 – 145.31 Mb
PubMed search	[1]	[2]

Protein CYR61 is a protein that in humans is encoded by the CYR61 gene.^[1]

CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.[supplied by OMIM]^[2]

References

1. ^ Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (May 1997). "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p". Oncogene 14 (14): 1753–7. doi:10.1038/sj.onc.1200986. PMID 9135077. 
2. ^ "Entrez Gene: CYR61 cysteine-rich, angiogenic inducer, 61". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3491. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Genini M, Schwalbe P, Scholl FA, Schäfer BW (1996). "Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma". Int. J. Cancer 66 (4): 571–7. doi:10.1002/(SICI)1097-0215(19960516)66:4<571::AID-IJC24>3.0.CO;2-9. PMID 8635876. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Kireeva ML, Lam SC, Lau LF (1998). "Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3". J. Biol. Chem. 273 (5): 3090–6. doi:10.1074/jbc.273.5.3090. PMID 9446626. 
• Kolesnikova TV, Lau LF (1998). "Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells". Oncogene 16 (6): 747–54. doi:10.1038/sj.onc.1201572. PMID 9488038. 
• Schütze N, Lechner A, Groll C, et al. (1998). "The human analog of murine cystein rich protein 61 [correction of 16] is a 1alpha,25-dihydroxyvitamin D3 responsive immediate early gene in human fetal osteoblasts: regulation by cytokines, growth factors, and serum". Endocrinology 139 (4): 1761–70. doi:10.1210/en.139.4.1761. PMID 9528960. 
• Martinerie C, Viegas-Pequignot E, Nguyen VC, Perbal B (1998). "Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system". MP, Mol. Pathol. 50 (6): 310–6. doi:10.1136/mp.50.6.310. PMC 379665. PMID 9536281. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=379665. 
• Babic AM, Kireeva ML, Kolesnikova TV, Lau LF (1998). "CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6355–60. doi:10.1073/pnas.95.11.6355. PMC 27701. PMID 9600969. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27701. 
• Jedsadayanmata A, Chen CC, Kireeva ML, et al. (1999). "Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)". J. Biol. Chem. 274 (34): 24321–7. doi:10.1074/jbc.274.34.24321. PMID 10446209. 
• Chen N, Chen CC, Lau LF (2000). "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans". J. Biol. Chem. 275 (32): 24953–61. doi:10.1074/jbc.M003040200. PMID 10821835. 
• Albrecht C, von Der Kammer H, Mayhaus M, et al. (2000). "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61". J. Biol. Chem. 275 (37): 28929–36. doi:10.1074/jbc.M003053200. PMID 10852911. 
• Chen CC, Chen N, Lau LF (2001). "The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts". J. Biol. Chem. 276 (13): 10443–52. doi:10.1074/jbc.M008087200. PMID 11120741. 
• Grzeszkiewicz TM, Kirschling DJ, Chen N, Lau LF (2001). "CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain". J. Biol. Chem. 276 (24): 21943–50. doi:10.1074/jbc.M100978200. PMID 11287419. 
• Chen CC, Mo FE, Lau LF (2002). "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts". J. Biol. Chem. 276 (50): 47329–37. doi:10.1074/jbc.M107666200. PMID 11584015. 
• Tamura I, Rosenbloom J, Macarak E, Chaqour B (2001). "Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways". Am. J. Physiol., Cell Physiol. 281 (5): C1524–32. PMID 11600415. 
• Xie D, Nakachi K, Wang H, et al. (2002). "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features". Cancer Res. 61 (24): 8917–23. PMID 11751417. 
• Leng E, Malcolm T, Tai G, et al. (2002). "Organization and expression of the Cyr61 gene in normal human fibroblasts". J. Biomed. Sci. 9 (1): 59–67. PMID 11810026. 
• Tsai MS, Bogart DF, Li P, et al. (2002). "Expression and regulation of Cyr61 in human breast cancer cell lines". Oncogene 21 (6): 964–73. doi:10.1038/sj.onc.1205131. PMID 11840342. 
• Schober JM, Chen N, Grzeszkiewicz TM, et al. (2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions". Blood 99 (12): 4457–65. doi:10.1182/blood.V99.12.4457. PMID 12036876.