WISP1

WNT1 inducible signaling pathway protein 1, also known as WISP1, is a human gene.cite web | title = Entrez Gene: WISP1 WNT1 inducible signaling pathway protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8840| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.cite web | title = Entrez Gene: WISP1 WNT1 inducible signaling pathway protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8840| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pennica D, Swanson TA, Welsh JW, "et al." |title=WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14717–22 |year= 1999 |pmid= 9843955 |doi=
*cite journal | author=Xu L, Corcoran RB, Welsh JW, "et al." |title=WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. |journal=Genes Dev. |volume=14 |issue= 5 |pages= 585–95 |year= 2000 |pmid= 10716946 |doi=
*cite journal | author=Tanaka S, Sugimachi K, Saeki H, "et al." |title=A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. |journal=Oncogene |volume=20 |issue= 39 |pages= 5525–32 |year= 2001 |pmid= 11571650 |doi= 10.1038/sj.onc.1204723
*cite journal | author=Desnoyers L, Arnott D, Pennica D |title=WISP-1 binds to decorin and biglycan. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47599–607 |year= 2002 |pmid= 11598131 |doi= 10.1074/jbc.M108339200
*cite journal | author=Xie D, Nakachi K, Wang H, "et al." |title=Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. |journal=Cancer Res. |volume=61 |issue= 24 |pages= 8917–23 |year= 2002 |pmid= 11751417 |doi=
*cite journal | author=Su F, Overholtzer M, Besser D, Levine AJ |title=WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. |journal=Genes Dev. |volume=16 |issue= 1 |pages= 46–57 |year= 2002 |pmid= 11782444 |doi= 10.1101/gad.942902
*cite journal | author=Saxena N, Banerjee S, Sengupta K, "et al." |title=Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines. |journal=Mol. Cell. Biochem. |volume=228 |issue= 1-2 |pages= 99–104 |year= 2002 |pmid= 11855747 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Soon LL, Yie TA, Shvarts A, "et al." |title=Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11465–70 |year= 2003 |pmid= 12529380 |doi= 10.1074/jbc.M210945200
*cite journal | author=Tanaka S, Sugimachi K, Kameyama T, "et al." |title=Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. |journal=Hepatology |volume=37 |issue= 5 |pages= 1122–9 |year= 2003 |pmid= 12717393 |doi= 10.1053/jhep.2003.50187
*cite journal | author=Hocevar BA, Mou F, Rennolds JL, "et al." |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2). |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Cervello M, Giannitrapani L, Labbozzetta M, "et al." |title=Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells. |journal=Ann. N. Y. Acad. Sci. |volume=1028 |issue= |pages= 432–9 |year= 2005 |pmid= 15650268 |doi= 10.1196/annals.1322.051
*cite journal | author=Nusbaum C, Mikkelsen TS, Zody MC, "et al." |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Yanagita T, Kubota S, Kawaki H, "et al." |title=Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. |journal=FEBS J. |volume=274 |issue= 7 |pages= 1655–65 |year= 2007 |pmid= 17381509 |doi= 10.1111/j.1742-4658.2007.05709.x
*cite journal | author=Davies SR, Watkins G, Mansel RE, Jiang WG |title=Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. |journal=Ann. Surg. Oncol. |volume=14 |issue= 6 |pages= 1909–18 |year= 2007 |pmid= 17406949 |doi= 10.1245/s10434-007-9376-x
*cite journal | author=Urano T, Narusawa K, Shiraki M, "et al." |title=Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. |journal=J. Bone Miner. Metab. |volume=25 |issue= 4 |pages= 253–8 |year= 2007 |pmid= 17593496 |doi= 10.1007/s00774-007-0757-9
*cite journal | author=Tian C, Zhou ZG, Meng WJ, "et al." |title=Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients. |journal=World J. Gastroenterol. |volume=13 |issue= 28 |pages= 3878–82 |year= 2007 |pmid= 17657846 |doi=
*cite journal | author=Yamashita T, Budhu A, Forgues M, Wang XW |title=Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. |journal=Cancer Res. |volume=67 |issue= 22 |pages= 10831–9 |year= 2007 |pmid= 18006828 |doi= 10.1158/0008-5472.CAN-07-0908

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